Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression
المؤلفون المشاركون
Liu, Zhelong
Zhang, Jianhua
Yan, Jiangtao
Wang, Yuping
Li, Yongsheng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The goal of this study is to investigate the association between oxidative stress and telomere length shortening in the comorbid depression and diabetes.
Therefore, 71 patients with newly diagnosed type 2 diabetes (T2D) and 52 subjects with normal glycemic level (control, Ctrl) were enrolled.
Depressive status was identified with the Depression Subscale of Hospital Anxiety and Depression Scale (HADS-D).
Leukocyte telomere length ratio (T/S ratio) was determined with quantitative PCR.
Oxidative stress status was evaluated with 8-hydroxy-desoxyguanosine (8-OHdG) assay kit.
Some other biochemical blood testing was also performed.
The data showed that T2D patients had higher proportion of depression evaluated by the HADS-D (x2=4.196, P=0.041).
T/S ratio was significantly negatively correlated with 8-OHdG, HADS-D, age, HbA1c, FPG, and HOMA-IR.
In addition, HADS-D was significantly positively correlated with HbA1c, FPG, HOMA-IR, and 8-OHdG.
Both HADS-D and 8-OHdG were the major independent predictors for T/S ratio.
This study indicates that oxidative stress contributes to both telomere length shortening and depression development in newly diagnosed type 2 diabetic patients, while in depression status, some other mechanisms besides oxidative stress may also affect the telomere length.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Zhelong& Zhang, Jianhua& Yan, Jiangtao& Wang, Yuping& Li, Yongsheng. 2014. Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047082
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Zhelong…[et al.]. Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047082
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Zhelong& Zhang, Jianhua& Yan, Jiangtao& Wang, Yuping& Li, Yongsheng. Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047082
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047082
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر