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Epicatechin and Catechin Modulate Endothelial Activation Induced by Platelets of Patients with Peripheral Artery Disease
المؤلفون المشاركون
De Falco, Elena
Carnevale, Roberto
Loffredo, Lorenzo
Pignatelli, Pasquale
Chimenti, Isotta
Peruzzi, Mariangela
Nocella, Cristina
Bartimoccia, S.
Bucci, T.
Biondi-Zoccai, G.
Frati, G.
Violi, Francesco
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Platelet activation contributes to the alteration of endothelial function, a critical initial step in atherogenesis through the production and release of prooxidant mediators.
There is uncertainty about the precise role of polyphenols in interaction between platelets and endothelial cells (ECs).
We aimed to investigate whether polyphenols are able to reduce endothelial activation induced by activated platelets.
First, we compared platelet activation and flow-mediated dilation (FMD) in 10 healthy subjects (HS) and 10 patients with peripheral artery disease (PAD).
Then, we evaluated the effect of epicatechin plus catechin on platelet-HUVEC interaction by measuring soluble cell adhesion molecules (CAMs), NOx production, and eNOS phosphorylation (p-eNOS) in HUVEC.
Compared to HS, PAD patients had enhanced platelet activation.
Conversely, PAD patients had lower FMD than HS.
Supernatant of activated platelets from PAD patients induced an increase of sCAMs release and a decrease of p-eNOS and nitric oxide (NO) bioavailability compared to unstimulated HUVEC.
Coincubation of HUVEC, with supernatant of PAD platelets patients, pretreated with a scalar dose of the polyphenols, resulted in a decrease of sCAMs release and in an increase of p-eNOS and NO bioavailability.
This study demonstrates that epicatechin plus catechin reduces endothelial activation induced by activated platelets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carnevale, Roberto& Loffredo, Lorenzo& Nocella, Cristina& Bartimoccia, S.& Bucci, T.& De Falco, Elena…[et al.]. 2014. Epicatechin and Catechin Modulate Endothelial Activation Induced by Platelets of Patients with Peripheral Artery Disease. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047088
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carnevale, Roberto…[et al.]. Epicatechin and Catechin Modulate Endothelial Activation Induced by Platelets of Patients with Peripheral Artery Disease. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047088
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carnevale, Roberto& Loffredo, Lorenzo& Nocella, Cristina& Bartimoccia, S.& Bucci, T.& De Falco, Elena…[et al.]. Epicatechin and Catechin Modulate Endothelial Activation Induced by Platelets of Patients with Peripheral Artery Disease. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047088
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047088
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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