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On the Molecular Pharmacology of Resveratrol on Oxidative Burst Inhibition in Professional Phagocytes
المؤلفون المشاركون
Šmidrkal, Jan
Harmatha, Juraj
Pekarova, Michaela
Drabikova, Katarina
Jancinova, Viera
Ambrozova, Gabriela
Lojek, Antonin
Ciz, Milan
Perečko, Tomáš
Nosál’, Radomír
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Resveratrol—3,5,4′-trihydroxystilbene—possesses antioxidant activities in vitro.
It dose-dependently inhibited the generation of peroxyl, hydroxyl, peroxides, and lipid peroxidation products in cell free systems.
Oxidative burst of whole human blood stimulated with PMA, fMLP, OpZ, and A23187 was inhibited in a concentration-dependent way, indicating suppression of both receptor and nonreceptor activated chemiluminescence by resveratrol.
Results from isolated human neutrophils revealed that resveratrol was active extracellularly as well as intracellularly in inhibiting the generation of reactive oxygen species.
Liberation of ATP and analysis of apoptosis showed that in the concentration of 100 μM, resveratrol did not change the viability and integrity of isolated neutrophils.
Western blot analysis documented that resveratrol in concentrations of 10 and 100 μM significantly decreased PMA-induced phosphorylation of PKC α/βII.
Dose-dependent inhibition of nitrite production and iNOS protein expression in RAW 264.7 cells indicated possible interference of resveratrol with reactive nitrogen radical generation in professional phagocytes.
The results suggest that resveratrol represents an effective naturally occurring substance with potent pharmacological effect on oxidative burst of human neutrophils and nitric oxide production by macrophages.
It should be further investigated for its pharmacological activity against oxidative stress in ischaemia reperfusion, inflammation, and other pathological conditions, particularly neoplasia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nosál’, Radomír& Drabikova, Katarina& Jancinova, Viera& Perečko, Tomáš& Ambrozova, Gabriela& Ciz, Milan…[et al.]. 2014. On the Molecular Pharmacology of Resveratrol on Oxidative Burst Inhibition in Professional Phagocytes. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047093
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nosál’, Radomír…[et al.]. On the Molecular Pharmacology of Resveratrol on Oxidative Burst Inhibition in Professional Phagocytes. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047093
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nosál’, Radomír& Drabikova, Katarina& Jancinova, Viera& Perečko, Tomáš& Ambrozova, Gabriela& Ciz, Milan…[et al.]. On the Molecular Pharmacology of Resveratrol on Oxidative Burst Inhibition in Professional Phagocytes. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047093
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047093
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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