Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction
المؤلفون المشاركون
Janicki, Joseph S.
Li, Siying
Wang, Wenjuan
Niu, Ting
Wang, Hui
Li, Bin
Shao, Lei
Lai, Yimu
Li, Huanjie
Wang, Xing Li
Tang, Dongqi
Cui, Taixing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-06
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The anticancer therapy of doxorubicin (Dox) has been limited by its acute and chronic cardiotoxicity.
In addition to a causative role of oxidative stress, autophagy appears to play an important role in the regulation of Dox-induced cardiotoxicity.
However, the underlying mechanisms remain unclear.
Accordingly, we explored a role of nuclear factor erythroid-2 related factor 2 (Nrf2) in Dox-induced cardiomyopathy with a focus on myocardial oxidative stress and autophagic activity.
In wild type (WT) mice, a single intraperitoneal injection of 25 mg/kg Dox rapidly induced cardiomyocyte necrosis and cardiac dysfunction, which were associated with oxidative stress, impaired autophagy, and accumulated polyubiquitinated protein aggregates.
However, these Dox-induced adverse effects were exaggerated in Nrf2 knockout (Nrf2−/−) mice.
In cultured cardiomyocytes, overexpression of Nrf2 increased the steady levels of LC3-II, ameliorated Dox-induced impairment of autophagic flux and accumulation of ubiquitinated protein aggregates, and suppressed Dox-induced cytotoxicity, whereas knockdown of Nrf2 exerted opposite effects.
Moreover, the exaggerated adverse effects in Dox-intoxicated Nrf2 depleted cardiomyocytes were dramatically attenuated by forced activation of autophagy via overexpression of autophagy related gene 5 (Atg5).
Thus, these results suggest that Nrf2 is likely an endogenous suppressor of Dox-induced cardiotoxicity by controlling both oxidative stress and autophagy in the heart.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Siying& Wang, Wenjuan& Niu, Ting& Wang, Hui& Li, Bin& Shao, Lei…[et al.]. 2014. Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1047108
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Siying…[et al.]. Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1047108
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Siying& Wang, Wenjuan& Niu, Ting& Wang, Hui& Li, Bin& Shao, Lei…[et al.]. Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1047108
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047108
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر