Oxidative Stress and Metabolic Pathologies: From an Adipocentric Point of View
المؤلفون المشاركون
Le Lay, Soazig
Simard, Gilles
Martinez, Maria Carmen
Andriantsitohaina, Ramaroson
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-17
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Oxidative stress plays a pathological role in the development of various diseases including diabetes, atherosclerosis, or cancer.
Systemic oxidative stress results from an imbalance between oxidants derivatives production and antioxidants defenses.
Reactive oxygen species (ROS) are generally considered to be detrimental for health.
However, evidences have been provided that they can act as second messengers in adaptative responses to stress.
Obesity represents a major risk factor for deleterious associated pathologies such as type 2 diabetes, liver, and coronary heart diseases.
Many evidences regarding obesity-induced oxidative stress accumulated over the past few years based on established correlations of biomarkers or end-products of free-radical-mediated oxidative stress with body mass index.
The hypothesis that oxidative stress plays a significant role in the development of metabolic disorders, especially insulin-resistance state, is supported by several studies where treatments reducing ROS production reverse metabolic alterations, notably through improvement of insulin sensitivity, hyperlipidemia, or hepatic steatosis.
In this review, we will develop the mechanistic links between oxidative stress generated by adipose tissue in the context of obesity and its impact on metabolic complications development.
We will also attempt to discuss potential therapeutic approaches targeting obesity-associated oxidative stress in order to prevent associated-metabolic complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Le Lay, Soazig& Simard, Gilles& Martinez, Maria Carmen& Andriantsitohaina, Ramaroson. 2014. Oxidative Stress and Metabolic Pathologies: From an Adipocentric Point of View. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1047162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Le Lay, Soazig…[et al.]. Oxidative Stress and Metabolic Pathologies: From an Adipocentric Point of View. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-18.
https://search.emarefa.net/detail/BIM-1047162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Le Lay, Soazig& Simard, Gilles& Martinez, Maria Carmen& Andriantsitohaina, Ramaroson. Oxidative Stress and Metabolic Pathologies: From an Adipocentric Point of View. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1047162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر