Obesity and the Odds of Weight Gain following Androgen Deprivation Therapy for Prostate Cancer
المؤلفون المشاركون
Braunstein, Lior Z.
Chen, Ming-Hui
Loffredo, Marian
Kantoff, Philip W.
D'Amico, Anthony V.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Increasing body mass index (BMI) is associated with increased risk of mortality; however, quantifying weight gain in men undergoing androgen deprivation therapy (ADT) for prostate cancer (PC) remains unexplored.
Methods.
Between 1995 and 2001, 206 men were enrolled in a randomized trial evaluating the survival difference of adding 6 months of ADT to radiation therapy (RT).
BMI measurements were available in 171 men comprising the study cohort.
The primary endpoint was weight gain of ≥10 lbs by 6-month followup.
Logistic regression analysis was performed to assess whether baseline BMI or treatment received was associated with this endpoint adjusting for known prognostic factors.
Results.
By the 6-month followup, 12 men gained ≥10 lbs, of which 10 (83%) received RT + ADT and, of these, 7 (70%) were obese at randomization.
Men treated with RT as compared to RT + ADT were less likely to gain ≥10 lbs (adjusted odds ratio (AOR): 0.18 [95% CI: 0.04–0.89]; P=0.04), whereas this risk increased with increasing BMI (AOR: 1.15 [95% CI: 1.01–1.31]; P=0.04).
Conclusions.
Consideration should be given to avoid ADT in obese men with low- or favorable-intermediate risk PC where improved cancer control has not been observed, but shortened life expectancy from weight gain is expected.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Braunstein, Lior Z.& Chen, Ming-Hui& Loffredo, Marian& Kantoff, Philip W.& D'Amico, Anthony V.. 2014. Obesity and the Odds of Weight Gain following Androgen Deprivation Therapy for Prostate Cancer. Prostate Cancer،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047181
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Braunstein, Lior Z.…[et al.]. Obesity and the Odds of Weight Gain following Androgen Deprivation Therapy for Prostate Cancer. Prostate Cancer No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047181
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Braunstein, Lior Z.& Chen, Ming-Hui& Loffredo, Marian& Kantoff, Philip W.& D'Amico, Anthony V.. Obesity and the Odds of Weight Gain following Androgen Deprivation Therapy for Prostate Cancer. Prostate Cancer. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047181
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047181
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر