Burden of Illness in Prostate Cancer Patients with a Low-to-Moderate Risk of Progression: A One-Year, Pan-European Observational Study
المؤلفون المشاركون
Burgos Revilla, F. J.
Bjartell, Anders
Somerville, Matthew
Palacios, Juan-Manuel
Benjamin, Laure
Black, Libby
Castro, Ramiro
Selli, Cesare
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To assess the impact of low-to-moderate risk prostate cancer on patients’ quality of life (QoL) at diagnosis and within the first year of treatment.
Subjects and Methods.
Men ( n = 672 ) aged 50–75 years with prostate cancer (Gleason score ≤ 7 , PSA ≤ 20 ng/mL and clinical staging T1c–T2b) were enrolled in five European countries.
Patients completed five questionnaires, including EORTC Quality of Life Questionnaire—Prostate Cancer 25 (QLQ-PR25) and EORTC Quality of Life Questionnaire—Cancer 30 (QLQ-C30).
Questionnaires were completed at baseline, at 3 months and 12 months after starting treatment.
The primary endpoint was the change in QLQ-PR25 urinary symptoms subscale score from baseline to the assessment at 3 months.
Results.
Mean (SD) age was 65.0 (5.7) years and 400 (66%) men had Gleason score ≤6 prostate cancer.
The most frequently used initial treatment was radical prostatectomy (71% of patients).
QLQ-PR25 urinary symptoms subscale score was significantly increased at 3 months ( P < 0.001 ), indicating that urinary symptoms worsened after treatment.
The score was lower at 12 months than at 3 months, but it was still significantly higher than at baseline ( P < 0.001 ).
Hormonal treatment-related symptoms, sexual functioning, and sexual activity scores significantly worsened at 3 and 12 months (all P < 0.001 ).
For the QLQ-C30 questionnaire, global health status/QoL score significantly decreased at month 3 but was not different from baseline by month 12.
Scales for physical, role, and social functioning, and fatigue, showed significant deterioration at 3 and 12 months.
Conclusions.
Low-to-moderate risk prostate cancer may have a substantial effect on patients’ QoL within one year following treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Selli, Cesare& Bjartell, Anders& Burgos Revilla, F. J.& Somerville, Matthew& Palacios, Juan-Manuel& Benjamin, Laure…[et al.]. 2014. Burden of Illness in Prostate Cancer Patients with a Low-to-Moderate Risk of Progression: A One-Year, Pan-European Observational Study. Prostate Cancer،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047188
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Selli, Cesare…[et al.]. Burden of Illness in Prostate Cancer Patients with a Low-to-Moderate Risk of Progression: A One-Year, Pan-European Observational Study. Prostate Cancer No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047188
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Selli, Cesare& Bjartell, Anders& Burgos Revilla, F. J.& Somerville, Matthew& Palacios, Juan-Manuel& Benjamin, Laure…[et al.]. Burden of Illness in Prostate Cancer Patients with a Low-to-Moderate Risk of Progression: A One-Year, Pan-European Observational Study. Prostate Cancer. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047188
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047188
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر