Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population
المؤلفون المشاركون
Perry, Anthony S.
Furusato, Bungo
Ghosh, Sourav
Nagle, Raymond B.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Levels of the protein kinase aPKC have been previously correlated with prostate cancer prognosis in a British cohort.
However, prostate cancer incidence and progression rates, as well as genetic changes in this disease, show strong ethnic variance, particularly in Asian populations.
Objective.
The aim of this study was to validate association of aPKC expression with prostatic adenocarcinoma stages in a Japanese cohort.
Methods.
Tissue microarrays consisting of 142 malignant prostate cancer cases and 21 benign prostate tissues were subject to immunohistological staining for aPKC.
aPKC staining intensity was scored by three independent pathologists and categorized as absent (0), dim (1+), intermediate (2+), and bright (3+).
aPKC staining intensities were correlated with Gleason score and tumor stage.
Results.
Increased aPKC staining was observed in malignant prostate cancer, in comparison to benign tissue.
Additionally, aPKC staining levels correlated with Gleason score and tumor stage.
Our results extend the association of aPKC with prostate cancer to a Japanese population and establish the suitability of aPKC as a universal prostate cancer biomarker that performs consistently across ethnicities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Perry, Anthony S.& Furusato, Bungo& Nagle, Raymond B.& Ghosh, Sourav. 2014. Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population. Prostate Cancer،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1047190
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Perry, Anthony S.…[et al.]. Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population. Prostate Cancer No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1047190
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Perry, Anthony S.& Furusato, Bungo& Nagle, Raymond B.& Ghosh, Sourav. Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population. Prostate Cancer. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1047190
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047190
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر