Long-Term Efficacy and Tolerability of Abdominal Once-Yearly Histrelin Acetate Subcutaneous Implants in Patients with Advanced Prostate Cancer
المؤلفون المشاركون
Woolen, Sean
Holzmeyer, Cameron
Nesbitt, Emily
Siami, Paul F.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-04
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objectives.
Long-term assessment of the efficacy and tolerability of subcutaneous abdominal histrelin acetate implants that have been inserted for more than two years.
Materials and Methods.
Retrospective data collected over a six-year period at a single center from charts of 113 patients who received the subcutaneous abdominal histrelin acetate implant.
Results.
Following insertion of the first implant, 92.1% and 91.8% of patients had a serum testosterone level of ≤30 ng/dL at 24 and 48 weeks, respectively.
Serum testosterone levels remained at <30 ng/dL for 96% of patients at two years and for 100% of patients at 3, 4, and 5 years.
The testosterone levels remained significantly less than baseline ( P < 0.05 ) .
Six patients (5.3%) had androgen-independent progression when followed up on the long term, increasing the mean serum PSA at 3, 4, and 5 years to 35.0 µg/L ( n = 22 ) , 30.7 µg/L ( n = 13 ) , and 132.9 µg/L ( n = 8 ) , respectively.
The mean serum PSA was significantly greater than baseline during these years ( P < 0.05 ) .
Eight patients (7.1%) experienced minor, but not serious, adverse events from the histrelin acetate.
Conclusion.
Subcutaneous abdominal histrelin acetate implants are an effective long-term and well-tolerated administration method for treating patients with advanced prostate cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Woolen, Sean& Holzmeyer, Cameron& Nesbitt, Emily& Siami, Paul F.. 2014. Long-Term Efficacy and Tolerability of Abdominal Once-Yearly Histrelin Acetate Subcutaneous Implants in Patients with Advanced Prostate Cancer. Prostate Cancer،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1047191
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Woolen, Sean…[et al.]. Long-Term Efficacy and Tolerability of Abdominal Once-Yearly Histrelin Acetate Subcutaneous Implants in Patients with Advanced Prostate Cancer. Prostate Cancer No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1047191
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Woolen, Sean& Holzmeyer, Cameron& Nesbitt, Emily& Siami, Paul F.. Long-Term Efficacy and Tolerability of Abdominal Once-Yearly Histrelin Acetate Subcutaneous Implants in Patients with Advanced Prostate Cancer. Prostate Cancer. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1047191
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047191
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر