Natural History of Untreated Prostate Specific Antigen Radiorecurrent Prostate Cancer in Men with Favorable Prognostic Indicators
المؤلفون المشاركون
Chen, Ming-Hui
Loffredo, Marian
Kantoff, Philip W.
D'Amico, Anthony V.
Martin, Neil E.
Beard, Clair J.
Nguyen, Paul L.
Renshaw, Andrew A.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background and Purpose.
Life expectancy data could identify men with favorable post-radiation prostate-specific antigen (PSA) failure kinetics unlikely to require androgen deprivation therapy (ADT).
Materials and Methods.
Of 206 men with unfavorable-risk prostate cancer in a randomized trial of radiation versus radiation and ADT, 53 experienced a PSA failure and were followed without salvage ADT.
Comorbidity, age and established prognostic factors were assessed for relationship to death using Cox regression analyses.
Results.
The median age at failure, interval to PSA failure, and PSA doubling time were 76.6 years (interquartile range [IQR]: 71.8–79.3), 49.1 months (IQR: 37.7–87.4), and 25 months (IQR: 13.1–42.8), respectively.
After a median follow up of 4.0 years following PSA failure, 45% of men had died, none from prostate cancer and no one had developed metastases.
Both increasing age at PSA failure (HR: 1.14; 95% CI: 1.03–1.25; P = 0.008 ) and the presence of moderate to severe comorbidity (HR: 12.5; 95% CI: 3.81–41.0; P < 0.001 ) were significantly associated with an increased risk of death.
Conclusions.
Men over the age of 76 with significant comorbidity and a PSA doubling time >2 years following post-radiation PSA failure appear to be good candidates for observation without ADT intervention.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Martin, Neil E.& Chen, Ming-Hui& Beard, Clair J.& Nguyen, Paul L.& Loffredo, Marian& Renshaw, Andrew A.…[et al.]. 2014. Natural History of Untreated Prostate Specific Antigen Radiorecurrent Prostate Cancer in Men with Favorable Prognostic Indicators. Prostate Cancer،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047198
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Martin, Neil E.…[et al.]. Natural History of Untreated Prostate Specific Antigen Radiorecurrent Prostate Cancer in Men with Favorable Prognostic Indicators. Prostate Cancer No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047198
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Martin, Neil E.& Chen, Ming-Hui& Beard, Clair J.& Nguyen, Paul L.& Loffredo, Marian& Renshaw, Andrew A.…[et al.]. Natural History of Untreated Prostate Specific Antigen Radiorecurrent Prostate Cancer in Men with Favorable Prognostic Indicators. Prostate Cancer. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047198
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047198
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر