Minimal Clinically Important Difference in Parkinson’s Disease as Assessed in Pivotal Trials of Pramipexole Extended Release
المؤلفون المشاركون
Schapira, Anthony H. V.
Hauser, Robert A.
Gordon, Mark Forrest
Mizuno, Yoshikuni
Poewe, Werner
Barone, Paolo
Debieuvre, Catherine
Fräßdorf, Mandy
Rascol, Olivier
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The minimal clinically important difference (MCID) is the smallest change in an outcome measure that is meaningful for patients.
Objectives.
To calculate the MCID for Unified Parkinson’s Disease Rating Scale (UPDRS) scores in early Parkinson’s disease (EPD) and for UPDRS scores and “OFF” time in advanced Parkinson’s disease (APD).
Methods.
We analyzed data from two pivotal, double-blind, parallel-group trials of pramipexole ER that included pramipexole immediate release (IR) as an active comparator.
We calculated MCID as the mean change in subjects who received active treatment and rated themselves “a little better” on patient global impression of improvement (PGI-I) minus the mean change in subjects who received placebo and rated themselves unchanged.
Results.
MCIDs in EPD (pramipexole ER, pramipexole IR) for UPDRS II were −1.8 and −2.0, for UPDRS III −6.2 and −6.1, and for UPDRS II + III −8.0 and −8.1.
MCIDs in APD for UPDRS II were −1.8 and −2.3, for UPDRS III −5.2 and −6.5, and for UPDRS II + III −7.1 and −8.8.
MCID for “OFF” time (pramipexole ER, pramipexole IR) was −1.0 and −1.3 hours.
Conclusions.
A range of MCIDs is emerging in the PD literature that provides the basis for power calculations and interpretation of clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hauser, Robert A.& Gordon, Mark Forrest& Mizuno, Yoshikuni& Poewe, Werner& Barone, Paolo& Schapira, Anthony H. V.…[et al.]. 2014. Minimal Clinically Important Difference in Parkinson’s Disease as Assessed in Pivotal Trials of Pramipexole Extended Release. Parkinson’s Disease،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047208
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hauser, Robert A.…[et al.]. Minimal Clinically Important Difference in Parkinson’s Disease as Assessed in Pivotal Trials of Pramipexole Extended Release. Parkinson’s Disease No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047208
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hauser, Robert A.& Gordon, Mark Forrest& Mizuno, Yoshikuni& Poewe, Werner& Barone, Paolo& Schapira, Anthony H. V.…[et al.]. Minimal Clinically Important Difference in Parkinson’s Disease as Assessed in Pivotal Trials of Pramipexole Extended Release. Parkinson’s Disease. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047208
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047208
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر