Neuroprotective Properties of a Standardized Extract from Myracrodruon urundeuva Fr. All. (Aroeira-Do-Sertão), as Evaluated by a Parkinson’s Disease Model in Rats
المؤلفون المشاركون
Brito, Gerly Anne de Castro
Calou, Iana
Bandeira, Mary Anne
Aguiar-Galvão, Wellida
Siqueira, Rafaelly
Neves, Kelly Rose
Viana, Glauce Socorro de Barros
Cerqueira, Gilberto Santos
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Myracrodruon urundeuva Fr.
All.
(Anacardiaceae) is a Brazilian medicinal species, which is common to the Northeastern Brazilian semiarid region, whose stem-bark is widely used in folk medicine.
It is an endangered species, presenting as main bioactive components tannins and chalcones.
In this work, we studied the neuroprotective effects of a standardized extract from cultivated M.
urundeuva (SEMU), in a model of Parkinson’s disease.
Thus, a unilateral injection of 6-OHDA was done into the rat right stratum.
The animals were submitted to stereotaxic surgery, then treated with SEMU (5, 10, 20, or 40 mg/kg, p.o.) for 2 weeks, subjected to behavioral tests, and euthanized for striata dissections and neurochemical, histological, and immunohistochemical analyses.
We showed, for the first time, that SEMU reverted behavioral alterations seen in the 6-OHDA-lesioned group and partially blocked the decrease in DA and DOPAC contents.
The numbers of viable neurons and TH immunopositive cells were increased by SEMU.
In addition, the SEMU-treated 6-OHDA groups showed lower numbers of GFAP and OX-42 immunopositive cells.
The neuroprotective action of SEMU is possibly related to the antioxidant and anti-inflammatory properties of M.
urundeuva, pointing out to its potential use in the prevention or treatment of neurodegenerative conditions, such as Parkinson’s disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Calou, Iana& Bandeira, Mary Anne& Aguiar-Galvão, Wellida& Cerqueira, Gilberto Santos& Siqueira, Rafaelly& Neves, Kelly Rose…[et al.]. 2014. Neuroprotective Properties of a Standardized Extract from Myracrodruon urundeuva Fr. All. (Aroeira-Do-Sertão), as Evaluated by a Parkinson’s Disease Model in Rats. Parkinson’s Disease،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047214
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Calou, Iana…[et al.]. Neuroprotective Properties of a Standardized Extract from Myracrodruon urundeuva Fr. All. (Aroeira-Do-Sertão), as Evaluated by a Parkinson’s Disease Model in Rats. Parkinson’s Disease No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047214
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Calou, Iana& Bandeira, Mary Anne& Aguiar-Galvão, Wellida& Cerqueira, Gilberto Santos& Siqueira, Rafaelly& Neves, Kelly Rose…[et al.]. Neuroprotective Properties of a Standardized Extract from Myracrodruon urundeuva Fr. All. (Aroeira-Do-Sertão), as Evaluated by a Parkinson’s Disease Model in Rats. Parkinson’s Disease. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047214
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047214
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر