The Rate of Decline of Glomerular Filtration Rate May Not Be Associated with Polymorphism of the PPARγ2 Gene in Patients with Type 1 Diabetes and Nephropathy
المؤلفون المشاركون
Millward, Ann B.
Demaine, Andrew G.
Yang, Bingmei
Zhao, Hongxin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The aim of the study was to investigate whether a Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma 2 (PPARγ2) gene is associated with the progress of diabetic nephropathy in patients with type 1 diabetes.
197 Caucasian patients with type 1 diabetes and ethnically matched 151 normal healthy controls were genotyped for this polymorphism.
Results showed that there were no significant differences in the frequencies of the genotypes and alleles of the polymorphism between groups.
Multiple regression analysis in 77 patients demonstrated that the rate of decline in renal function in terms of glomerular filtration rate was significantly correlated to the baseline level of cholesterol (P=0.0014), mean diastolic blood pressure during follow-up period (P=0.019), and baseline level of HbA1c (P=0.022) adjusting for the effect of diabetes duration and gender, but no significant association was found between the polymorphism and the progression of diabetic nephropathy in our studied population.
In summary, our results show that the PPARγ2 polymorphism is unlikely to be associated with the development and progression of the diabetic nephropathy in patients with type 1 diabetes.
Further studies in different populations may be warranted to confirm our findings as the sample size in our study was relatively small.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Bingmei& Zhao, Hongxin& Millward, Ann B.& Demaine, Andrew G.. 2014. The Rate of Decline of Glomerular Filtration Rate May Not Be Associated with Polymorphism of the PPARγ2 Gene in Patients with Type 1 Diabetes and Nephropathy. PPAR Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047280
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Bingmei…[et al.]. The Rate of Decline of Glomerular Filtration Rate May Not Be Associated with Polymorphism of the PPARγ2 Gene in Patients with Type 1 Diabetes and Nephropathy. PPAR Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047280
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Bingmei& Zhao, Hongxin& Millward, Ann B.& Demaine, Andrew G.. The Rate of Decline of Glomerular Filtration Rate May Not Be Associated with Polymorphism of the PPARγ2 Gene in Patients with Type 1 Diabetes and Nephropathy. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047280
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047280
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر