New Insights into the PPAR γ Agonists for the Treatment of Diabetic Nephropathy
المؤلفون المشاركون
Sun, Ying
Yang, Guangrui
Zhang, Yue
Zhang, Aihua
Heiney, Kristina Marie
Huang, Songming
Jia, Zhanjun
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Diabetic nephropathy (DN) is a severe complication of diabetes and serves as the leading cause of chronic renal failure.
In the past decades, angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin II receptor blockers (ARBs) based first-line therapy can slow but cannot stop the progression of DN, which urgently requests the innovation of therapeutic strategies.
Thiazolidinediones (TZDs), the synthetic exogenous ligands of nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ), had been thought to be a promising candidate for strengthening the therapy of DN.
However, the severe adverse effects including fluid retention, cardiovascular complications, and bone loss greatly limited their use in clinic.
Recently, numerous novel PPARγ agonists involving the endogenous PPARγ ligands and selective PPARγ modulators (SPPARMs) are emerging as the promising candidates of the next generation of antidiabetic drugs instead of TZDs.
Due to the higher selectivity of these novel PPARγ agonists on the regulation of the antidiabetes-associated genes than that of the side effect-associated genes, they present fewer adverse effects than TZDs.
The present review was undertaken to address the advancements and the therapeutic potential of these newly developed PPARγ agonists in dealing with diabetic kidney disease.
At the same time, the new insights into the therapeutic strategies of DN based on the PPARγ agonists were fully addressed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jia, Zhanjun& Sun, Ying& Yang, Guangrui& Zhang, Aihua& Huang, Songming& Heiney, Kristina Marie…[et al.]. 2014. New Insights into the PPAR γ Agonists for the Treatment of Diabetic Nephropathy. PPAR Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047299
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jia, Zhanjun…[et al.]. New Insights into the PPAR γ Agonists for the Treatment of Diabetic Nephropathy. PPAR Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047299
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jia, Zhanjun& Sun, Ying& Yang, Guangrui& Zhang, Aihua& Huang, Songming& Heiney, Kristina Marie…[et al.]. New Insights into the PPAR γ Agonists for the Treatment of Diabetic Nephropathy. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047299
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047299
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر