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New Insights into the PPAR γ Agonists for the Treatment of Diabetic Nephropathy
Joint Authors
Sun, Ying
Yang, Guangrui
Zhang, Yue
Zhang, Aihua
Heiney, Kristina Marie
Huang, Songming
Jia, Zhanjun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is a severe complication of diabetes and serves as the leading cause of chronic renal failure.
In the past decades, angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin II receptor blockers (ARBs) based first-line therapy can slow but cannot stop the progression of DN, which urgently requests the innovation of therapeutic strategies.
Thiazolidinediones (TZDs), the synthetic exogenous ligands of nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ), had been thought to be a promising candidate for strengthening the therapy of DN.
However, the severe adverse effects including fluid retention, cardiovascular complications, and bone loss greatly limited their use in clinic.
Recently, numerous novel PPARγ agonists involving the endogenous PPARγ ligands and selective PPARγ modulators (SPPARMs) are emerging as the promising candidates of the next generation of antidiabetic drugs instead of TZDs.
Due to the higher selectivity of these novel PPARγ agonists on the regulation of the antidiabetes-associated genes than that of the side effect-associated genes, they present fewer adverse effects than TZDs.
The present review was undertaken to address the advancements and the therapeutic potential of these newly developed PPARγ agonists in dealing with diabetic kidney disease.
At the same time, the new insights into the therapeutic strategies of DN based on the PPARγ agonists were fully addressed.
American Psychological Association (APA)
Jia, Zhanjun& Sun, Ying& Yang, Guangrui& Zhang, Aihua& Huang, Songming& Heiney, Kristina Marie…[et al.]. 2014. New Insights into the PPAR γ Agonists for the Treatment of Diabetic Nephropathy. PPAR Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047299
Modern Language Association (MLA)
Jia, Zhanjun…[et al.]. New Insights into the PPAR γ Agonists for the Treatment of Diabetic Nephropathy. PPAR Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047299
American Medical Association (AMA)
Jia, Zhanjun& Sun, Ying& Yang, Guangrui& Zhang, Aihua& Huang, Songming& Heiney, Kristina Marie…[et al.]. New Insights into the PPAR γ Agonists for the Treatment of Diabetic Nephropathy. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047299