Correlation of Circulating Acid-Labile Subunit Levels with Insulin Sensitivity and Serum LDL Cholesterol in Patients with Type 2 Diabetes: Findings from a Prospective Study with Rosiglitazone
المؤلفون المشاركون
Chuang, Lee-Ming
Lai, Ying-Chuen
Li, Hung-Yuan
Wu, Ta-Jen
Jeng, Chi-Yuan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Silencing of acid-labile subunit (ALS) improved glucose metabolism in animal models.
The aim of this study is to evaluate the effects of rosiglitazone (RSG) on ALS levels in individuals with type 2 diabetes.
A randomized, double-blind, placebo-controlled trial was conducted.
Subjects with type 2 diabetes mellitus were randomly distributed to an RSG-treated ( n = 30 ) or a placebo ( n = 31 ) group.
Patients were evaluated prior to treatment at baseline and at 12 and 24 weeks after treatment.
At baseline, ALS levels were negatively associated with low-density lipoprotein cholesterol (LDLc) levels and homeostatic model assessment version 2 insulin sensitivity (HOMA2-%S).
Over 24 weeks, there was a significantly greater reduction in ALS levels in the nonobese RSG-treated individuals than placebo-treated group.
The effect of RSG on ALS was not significant in obese individuals.
Fasting plasma glucose and hemoglobin A1c were reduced, but total cholesterol and LDLc were increased, in patients on RSG.
Change in ALS levels predicted changes in total cholesterol and HOMA2-%S over time.
This study suggested a BMI-dependent effect of RSG treatment on ALS levels.
Reduction of ALS by RSG increases the risk of atherosclerosis in individuals with type 2 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lai, Ying-Chuen& Li, Hung-Yuan& Wu, Ta-Jen& Jeng, Chi-Yuan& Chuang, Lee-Ming. 2014. Correlation of Circulating Acid-Labile Subunit Levels with Insulin Sensitivity and Serum LDL Cholesterol in Patients with Type 2 Diabetes: Findings from a Prospective Study with Rosiglitazone. PPAR Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047307
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lai, Ying-Chuen…[et al.]. Correlation of Circulating Acid-Labile Subunit Levels with Insulin Sensitivity and Serum LDL Cholesterol in Patients with Type 2 Diabetes: Findings from a Prospective Study with Rosiglitazone. PPAR Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047307
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lai, Ying-Chuen& Li, Hung-Yuan& Wu, Ta-Jen& Jeng, Chi-Yuan& Chuang, Lee-Ming. Correlation of Circulating Acid-Labile Subunit Levels with Insulin Sensitivity and Serum LDL Cholesterol in Patients with Type 2 Diabetes: Findings from a Prospective Study with Rosiglitazone. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047307
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047307
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر