Clinical Applications of Mesenchymal Stem Cells in Chronic Diseases

المؤلفون المشاركون

Erratico, Silvia
Meregalli, Mirella
Torrente, Yvan
Sitzia, Clementina
Farini, Andrea

المصدر

Stem Cells International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-04-30

دولة النشر

مصر

عدد الصفحات

11

الملخص EN

Extraordinary progress in understanding several key features of stem cells has been made in the last ten years, including definition of the niche, and identification of signals regulating mobilization and homing as well as partial understanding of the mechanisms controlling self-renewal, commitment, and differentiation.

This progress produced invaluable tools for the development of rational cell therapy protocols that have yielded positive results in preclinical models of genetic and acquired diseases and, in several cases, have entered clinical experimentation with positive outcome.

Adult mesenchymal stem cells (MSCs) are nonhematopoietic cells with multilineage potential to differentiate into various tissues of mesodermal origin.

They can be isolated from bone marrow and other tissues and have the capacity to extensively proliferate in vitro.

Moreover, MSCs have also been shown to produce anti-inflammatory molecules which can modulate humoral and cellular immune responses.

Considering their regenerative potential and immunoregulatory effect, MSC therapy is a promising tool in the treatment of degenerative, inflammatory, and autoimmune diseases.

It is obvious that much work remains to be done to increase our knowledge of the mechanisms regulating development, homeostasis, and tissue repair and thus to provide new tools to implement the efficacy of cell therapy trials.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Farini, Andrea& Sitzia, Clementina& Erratico, Silvia& Meregalli, Mirella& Torrente, Yvan. 2014. Clinical Applications of Mesenchymal Stem Cells in Chronic Diseases. Stem Cells International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047505

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Farini, Andrea…[et al.]. Clinical Applications of Mesenchymal Stem Cells in Chronic Diseases. Stem Cells International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047505

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Farini, Andrea& Sitzia, Clementina& Erratico, Silvia& Meregalli, Mirella& Torrente, Yvan. Clinical Applications of Mesenchymal Stem Cells in Chronic Diseases. Stem Cells International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047505

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1047505