Understanding the Added Value of G-Protein-Coupled Receptor Heteromers

الملخص EN

G-protein-coupled receptors (GPCRs) constitute the most populated family of proteins within the human genome.

Since the early sixties work on GPCRs and on GPCR-mediated signaling has led to a number of awards, the most recent being the Nobel Prize in Chemistry for 2012.

The future of GPCRs research is surely based on their capacity for heteromerization.

Receptor heteromers offer a series of challenges that will help in providing success in academic/basic research and translation into more effective and safer drugs.