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Surgical Treatment of Perianal Fistulizing Crohn’s Disease: From Lay-Open to Cell-Based Therapy—An Overview
المؤلفون المشاركون
Pellino, Gianluca
Selvaggi, Francesco
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Background.
Perianal Crohn’s disease (CD) can be challenging.
Despite the high incidence of fistulizing CD, literature lacks clear guidelines.
Several medical, surgical, and combined treatment modalities have been proposed, but evidences are scarce.
Methods.
We searched the literature to assess the facets of perianal CD, with particular focus on complex fistulae.
Disease epidemiology, classification, diagnosis, activity scoring systems, and medical-surgical treatments were assessed.
Results.
Perianal fistulizing CD is common, frequently associated with upper gastrointestinal and colorectal CD.
Complex fistulas often require repeated treatments.
Continence is a major concern when dealing with repeated procedures.
A prudent pathway is to resolve active sepsis and to limit damages, delaying a definitive treatment to the time when acute phase has been controlled.
The improved diagnostic techniques allow better preoperative planning and are useful in monitoring the response to treatment.
Besides newer devices, cell-based treatments are promising tools which have recently enriched the treatment portfolio.
However, the need for proctectomy is still disturbingly high in CD patients with complex perianal fistulae.
Conclusions.
Perianal CD can impair quality of life and lead to need for proctectomy.
A staged approach is reasonable.
Treatment success can be improved by multimodal treatment and collaborative management by experienced gastroenterologists and surgeons.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pellino, Gianluca& Selvaggi, Francesco. 2014. Surgical Treatment of Perianal Fistulizing Crohn’s Disease: From Lay-Open to Cell-Based Therapy—An Overview. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1048469
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pellino, Gianluca& Selvaggi, Francesco. Surgical Treatment of Perianal Fistulizing Crohn’s Disease: From Lay-Open to Cell-Based Therapy—An Overview. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1048469
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pellino, Gianluca& Selvaggi, Francesco. Surgical Treatment of Perianal Fistulizing Crohn’s Disease: From Lay-Open to Cell-Based Therapy—An Overview. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1048469
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1048469
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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