Antiproliferative Effects of Methanolic Extracts of Cryptocarya concinna Hance Roots on Oral Cancer Ca9-22 and CAL 27 Cell Lines Involving Apoptosis, ROS Induction, and Mitochondrial Depolarization
المؤلفون المشاركون
Chang, Hsueh-Wei
Tang, Jen-Yang
Huang, Hurng-Wern
Chen, Ih-Sheng
Chung, Yi-An
Chang, Hsun-Shuo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Cryptocarya-derived natural products were reported to have several biological effects such as the antiproliferation of some cancers.
The possible antioral cancer effect of Cryptocarya-derived substances was little addressed as yet.
In this study, we firstly used the methanolic extracts of C.
concinna Hance roots (MECCrt) to evaluate its potential function in antioral cancer bioactivity.
We found that MECCrt significantly reduced cell viability of two oral cancer Ca9-22 and CAL 27 cell lines in dose-responsive manners ( P < 0.01 ).
The percentages of sub-G1 phase and annexin V-positive of MECCrt-treated Ca9-22 and CAL 27 cell lines significantly accumulated ( P < 0.01 ) in a dose-responsive manner as evidenced by flow cytometry.
These apoptotic effects were associated with the findings that intracellular ROS generation was induced in MECCrt-treated Ca9-22 and CAL 27 cell lines in dose-responsive and time-dependent manners ( P < 0.01 ).
In a dose-responsive manner, MECCrt also significantly reduced the mitochondrial membrane potential in these two cell lines ( P < 0.01 –0.05).
In conclusion, we demonstrated that MECCrt may have antiproliferative potential against oral cancer cells involving apoptosis, ROS generation, and mitochondria membrane depolarization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Hurng-Wern& Chung, Yi-An& Chang, Hsun-Shuo& Tang, Jen-Yang& Chen, Ih-Sheng& Chang, Hsueh-Wei. 2014. Antiproliferative Effects of Methanolic Extracts of Cryptocarya concinna Hance Roots on Oral Cancer Ca9-22 and CAL 27 Cell Lines Involving Apoptosis, ROS Induction, and Mitochondrial Depolarization. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1048620
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Hurng-Wern…[et al.]. Antiproliferative Effects of Methanolic Extracts of Cryptocarya concinna Hance Roots on Oral Cancer Ca9-22 and CAL 27 Cell Lines Involving Apoptosis, ROS Induction, and Mitochondrial Depolarization. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1048620
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Hurng-Wern& Chung, Yi-An& Chang, Hsun-Shuo& Tang, Jen-Yang& Chen, Ih-Sheng& Chang, Hsueh-Wei. Antiproliferative Effects of Methanolic Extracts of Cryptocarya concinna Hance Roots on Oral Cancer Ca9-22 and CAL 27 Cell Lines Involving Apoptosis, ROS Induction, and Mitochondrial Depolarization. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1048620
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1048620
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر