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Comparative Analysis of Cardiovascular Development Related Genes in Stem Cells Isolated from Deciduous Pulp and Adipose Tissue
المؤلفون المشاركون
Abu Kasim, Noor Hayaty
Musa, Sabri
Loo, Zhang Xin
Kunasekaran, Wijenthiran
Govindasamy, Vijayendran
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Human exfoliated deciduous teeth (SHED) and adipose stem cells (ASC) were suggested as alternative cell choice for cardiac regeneration.
However, the true functionability of these cells toward cardiac regeneration is yet to be discovered.
Hence, this study was carried out to investigate the innate biological properties of these cell sources toward cardiac regeneration.
Both cells exhibited indistinguishable MSCs characteristics.
Human stem cell transcription factor arrays were used to screen expression levels in SHED and ASC.
Upregulated expression of transcription factor (TF) genes was detected in both sources.
An almost equal percentage of > 2-fold changes were observed.
These TF genes fall under several cardiovascular categories with higher expressions which were observed in growth and development of blood vessel, angiogenesis, and vasculogenesis categories.
Further induction into cardiomyocyte revealed ASC to express more significantly cardiomyocyte specific markers compared to SHED during the differentiation course evidenced by morphology and gene expression profile.
Despite this, spontaneous cellular beating was not detected in both cell lines.
Taken together, our data suggest that despite being defined as MSCs, both ASC and SHED behave differently when they were cultured in a same cardiomyocytes culture condition.
Hence, vigorous characterization is needed before introducing any cell for treating targeted diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Loo, Zhang Xin& Kunasekaran, Wijenthiran& Govindasamy, Vijayendran& Musa, Sabri& Abu Kasim, Noor Hayaty. 2014. Comparative Analysis of Cardiovascular Development Related Genes in Stem Cells Isolated from Deciduous Pulp and Adipose Tissue. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1048653
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Loo, Zhang Xin…[et al.]. Comparative Analysis of Cardiovascular Development Related Genes in Stem Cells Isolated from Deciduous Pulp and Adipose Tissue. The Scientific World Journal No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1048653
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Loo, Zhang Xin& Kunasekaran, Wijenthiran& Govindasamy, Vijayendran& Musa, Sabri& Abu Kasim, Noor Hayaty. Comparative Analysis of Cardiovascular Development Related Genes in Stem Cells Isolated from Deciduous Pulp and Adipose Tissue. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1048653
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1048653
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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