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Bilayered Films Based on Novel Polymer Derivative for Improved Ocular Therapy of Gatifloxacin
المؤلفون المشاركون
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Context.
Thiomers could prove to be suitable mucoadhesives for fabrication of ocular inserts.
Objective.
The study intends to explore the application of thiolated sodium alginate (TSA) to the preparation of bilayered ocular inserts of gatifloxacin.
Methods.
Cysteine moieties were grafted onto sodium alginate (SA) and the resultant thiomer was characterized for relevant physicochemical properties.
Bilayered inserts were fabricated with a mucoadhesive immediate release layer composed of either SA or TSA and a sustained release layer composed of acrylates.
Films were prepared by solvent evaporation and evaluated for mechanical properties, drug content, and in vitro release.
Results and Discussion.
The synthesized TSA possessed 248.80 ± 49.7 μmol thiol groups/gm and its solutions thickened on standing due to disulphide bridging.
Its films showed improved mucoadhesion and also a strikingly beneficial property of resisting erosion and remaining as a hydrated adhesive layer for the duration of drug release.
The bilayered films were found to be flexible, with good folding endurance, uniform thickness, and appropriate drug content, and showed a release of about 80% of loaded gatifloxacin in 12 h.
Conclusion.
The study demonstrates promise in employing thiolated polymer in conjunction with acrylates for the design of ocular inserts for twice a day therapy with gatifloxacin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aher, Naval& Nair, Hema. 2014. Bilayered Films Based on Novel Polymer Derivative for Improved Ocular Therapy of Gatifloxacin. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049124
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aher, Naval& Nair, Hema. Bilayered Films Based on Novel Polymer Derivative for Improved Ocular Therapy of Gatifloxacin. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1049124
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aher, Naval& Nair, Hema. Bilayered Films Based on Novel Polymer Derivative for Improved Ocular Therapy of Gatifloxacin. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049124
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1049124
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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