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Development and Optimization of Polymeric Self-Emulsifying Nanocapsules for Localized Drug Delivery: Design of Experiment Approach
المؤلفون المشاركون
Wadhwa, Jyoti
Asthana, Abhay
Gupta, Sumeet
Shilkari Asthana, Gyati
Singh, Ranjit
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
The purpose of the present study was to formulate polymeric self-emulsifying curcumin nanocapsules with high encapsulation efficiency, good emulsification ability, and optimal globule size for localized targeting in the colon.
Formulations were prepared using modified quasiemulsion solvent diffusion method.
Concentration of formulation variables, namely, X 1 (oil), X 2 (polymeric emulsifier), and X 3 (adsorbent), was optimized by design of experiments using Box-Behnken design, for its impact on mean globule size ( Y 1 ) and encapsulation efficiency ( Y 2 ) of the formulation.
Polymeric nanocapsules with an average diameter of 100–180 nm and an encapsulation efficiency of 64.85 ± 0.12% were obtained.
In vitro studies revealed that formulations released the drug after 5 h lag time corresponding to the time to reach the colonic region.
Pronounced localized action was inferred from the plasma concentration profile ( C max 200 ng/mL) that depicts limited systemic absorption.
Roentgenography study confirms the localized presence of carrier (0–2 h in upper GIT; 2–4 h in small intestine; and 4–24 h in the lower intestine).
Optimized formulation showed significantly higher cytotoxicity (IC50 value 20.32 μM) in HT 29 colonic cancer cell line.
The present study demonstrates systematic development of polymeric self-emulsifying nanocapsule formulation of curcumin for localized targeting in colon.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wadhwa, Jyoti& Asthana, Abhay& Gupta, Sumeet& Shilkari Asthana, Gyati& Singh, Ranjit. 2014. Development and Optimization of Polymeric Self-Emulsifying Nanocapsules for Localized Drug Delivery: Design of Experiment Approach. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1049930
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wadhwa, Jyoti…[et al.]. Development and Optimization of Polymeric Self-Emulsifying Nanocapsules for Localized Drug Delivery: Design of Experiment Approach. The Scientific World Journal No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1049930
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wadhwa, Jyoti& Asthana, Abhay& Gupta, Sumeet& Shilkari Asthana, Gyati& Singh, Ranjit. Development and Optimization of Polymeric Self-Emulsifying Nanocapsules for Localized Drug Delivery: Design of Experiment Approach. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1049930
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1049930
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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