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Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats
المؤلفون المشاركون
Hsu, Sheng-Lung
Chen, I-Hung
Tong, Yat-Ching
Chung, Hsien-Hui
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Objective.
To investigate the change of loperamide-induced prostate relaxation in rats fed with high-fat diet (HFD).
Materials and Methods.
Adult male Wistar rats were divided into 2 groups: (1) control rats fed with normal chow and (2) rats fed with HFD for 6 months.
The prostate was removed for histology study.
Isolated prostate strips were hung in organ bath and precontracted with 1 μmol/L phenylephrine or 50 mmol/L KCl.
The relaxation responses to loperamide 0.1 to 10 μmol/L were recorded.
Western blotting analyses were performed for prostate μ-opioid receptors (MOR) and ATP-sensitive potassium ( K ATP ) channel proteins: sulfonylurea receptor (SUR) and inwardly rectifying potassium channel (Kir) 6.2 subunits.
Results.
Body weight, prostate weight, plasma levels of glucose, insulin, triglyceride, and cholesterol, as well as systolic blood pressure, were significantly increased in the HFD rats.
Histology showed prostatic hyperplasia in the HFD rat prostate.
Prostatic relaxation induced by loperamide was markedly reduced in HFD when compared to the control.
Protein expressions of MOR, SUR, and Kir 6.2 were decreased in HFD-fed rats.
Conclusion.
Loperamide-induced prostate relaxation is decreased in HFD rats due to reduced MOR and K ATP channel expressions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsu, Sheng-Lung& Chung, Hsien-Hui& Chen, I-Hung& Tong, Yat-Ching. 2014. Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1049940
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsu, Sheng-Lung…[et al.]. Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1049940
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsu, Sheng-Lung& Chung, Hsien-Hui& Chen, I-Hung& Tong, Yat-Ching. Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1049940
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1049940
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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