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Salvia miltiorrhiza Injection Ameliorates Renal Damage Induced by Lead Exposure in Mice
المؤلفون المشاركون
Song, Qiongtao
Zhang, Jianping
Chu, Li
Li, Lei
Zhang, Yuanyuan
Ma, Juanjuan
Dong, Weichong
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Exposure to lead (Pb) can induce kidney injury and our recent studies have found that Salvia miltiorrhiza (SM) injection, a traditional Chinese medicine, could protect against the organ injury induced by iron overload.
This study was designed to investigate the protective effects of SM injection on nephrotoxicity induced by Pb acetate in mice and to elucidate the potential mechanism(s).
Healthy male mice were randomly divided into four groups: control, Pb, low-dose Salvia miltiorrhiza (L-SM), and high-dose Salvia miltiorrhiza (H-SM).
SM injection dose dependently reduced the Pb accumulation in the kidney, decreased kidney coefficients, and ameliorated renal structure and function from the morphology analysis.
Meanwhile, SM administration downregulated serum levels of blood urea nitrogen (BUN) and creatinine (CR), decreased malondialdehyde (MAD) content, and increased activities of super oxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the kidney homogenate.
Moreover, SM injection reduced the level of renal apoptosis by immunohistochemical staining analysis.
Our findings implicate the therapeutic potential of SM injection for Pb-induced nephrotoxicity, which were at least partly due to the decrease of Pb accumulation, inhibition of lipid peroxidation, and suppression of renal apoptosis.
These results provided preliminary experimental support for Danshen as a therapeutic drug for Pb poisoning diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Lei& Zhang, Yuanyuan& Ma, Juanjuan& Dong, Weichong& Song, Qiongtao& Zhang, Jianping…[et al.]. 2014. Salvia miltiorrhiza Injection Ameliorates Renal Damage Induced by Lead Exposure in Mice. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050155
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Lei…[et al.]. Salvia miltiorrhiza Injection Ameliorates Renal Damage Induced by Lead Exposure in Mice. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1050155
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Lei& Zhang, Yuanyuan& Ma, Juanjuan& Dong, Weichong& Song, Qiongtao& Zhang, Jianping…[et al.]. Salvia miltiorrhiza Injection Ameliorates Renal Damage Induced by Lead Exposure in Mice. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050155
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1050155
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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