Changes in Iron Metabolism and Oxidative Status in STZ-Induced Diabetic Rats Treated with Bis(maltolato) Oxovanadium (IV) as an Antidiabetic Agent
المؤلفون المشاركون
Sánchez-González, Cristina
López-Chaves, Carlos
Gómez-Aracena, Jorge
Aranda, Pilar
Llopis, Juan
Trenzado, Cristina E.
López-Jurado, María
Montes-Bayón, María
Sanz-Medel, Alfredo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
The role of vanadium as a micronutrient and hypoglycaemic agent has yet to be fully clarified.
The present study was undertaken to investigate changes in the metabolism of iron and in antioxidant defences of diabetic STZ rats following treatment with vanadium.
Four groups were examined: control; diabetic; diabetic treated with 1 mgV/day; and Diabetic treated with 3 mgV/day.
The vanadium was supplied in drinking water as bis(maltolato) oxovanadium (IV) (BMOV).
The experiment had a duration of five weeks.
Iron was measured in food, faeces, urine, serum, muscle, kidney, liver, spleen, and femur.
Superoxide dismutase, catalase, NAD(P)H: quinone-oxidoreductase-1 (NQO1) activity, and protein carbonyl group levels in the liver were determined.
In the diabetic rats, higher levels of Fe absorbed, Fe content in kidney, muscle, and femur, and NQO1 activity were recorded, together with decreased catalase activity, in comparison with the control rats.
In the rats treated with 3 mgV/day, there was a significant decrease in fasting glycaemia, Fe content in the liver, spleen, and heart, catalase activity, and levels of protein carbonyl groups in comparison with the diabetic group.
In conclusion BMOV was a dose-dependent hypoglycaemic agent.
Treatment with 3 mgV/day provoked increased Fe deposits in the tissues, which promoted a protein oxidative damage in the liver.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sánchez-González, Cristina& López-Chaves, Carlos& Trenzado, Cristina E.& Aranda, Pilar& López-Jurado, María& Gómez-Aracena, Jorge…[et al.]. 2014. Changes in Iron Metabolism and Oxidative Status in STZ-Induced Diabetic Rats Treated with Bis(maltolato) Oxovanadium (IV) as an Antidiabetic Agent. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1050695
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sánchez-González, Cristina…[et al.]. Changes in Iron Metabolism and Oxidative Status in STZ-Induced Diabetic Rats Treated with Bis(maltolato) Oxovanadium (IV) as an Antidiabetic Agent. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1050695
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sánchez-González, Cristina& López-Chaves, Carlos& Trenzado, Cristina E.& Aranda, Pilar& López-Jurado, María& Gómez-Aracena, Jorge…[et al.]. Changes in Iron Metabolism and Oxidative Status in STZ-Induced Diabetic Rats Treated with Bis(maltolato) Oxovanadium (IV) as an Antidiabetic Agent. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1050695
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1050695
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر