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Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals
المؤلفون المشاركون
Glikin, Gerardo Claudio
Finocchiaro, Liliana María Elena
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-17
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Despite the important progress obtained in the treatment of some pets’ malignancies, new treatments need to be developed.
Being critical in cancer control and progression, the immune system’s appropriate modulation may provide effective therapeutic options.
In this review we summarize the outcomes of published immunogene therapy veterinary clinical trials reported by many research centers.
A variety of tumors such as canine melanoma, soft tissue sarcomas, osteosarcoma and lymphoma, feline fibrosarcoma, and equine melanoma were subjected to different treatment approaches.
Both viral and mainly nonviral vectors were used to deliver gene products as cytokines, xenogeneic tumor associated antigens, specific ligands, and proapoptotic regulatory factors.
In some cases autologous, allogenic, or xenogeneic transgenic cytokine producing cells were assayed.
In general terms, minor or no adverse collateral effects appeared during this kind of therapies and treated patients usually displayed a better course of the disease (longer survival, delayed or suppressed recurrence or metastatic spread, and improvement of the quality of life).
This suggests the utility of these methodologies as standard adjuvant treatments.
The encouraging outcomes obtained in companion animals support their ready application in veterinary clinical oncology and serve as preclinical proof of concept and safety assay for future human gene therapy trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Glikin, Gerardo Claudio& Finocchiaro, Liliana María Elena. 2014. Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1050745
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Glikin, Gerardo Claudio& Finocchiaro, Liliana María Elena. Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals. The Scientific World Journal No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1050745
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Glikin, Gerardo Claudio& Finocchiaro, Liliana María Elena. Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1050745
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1050745
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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