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Nanospray Drying as a Novel Technique for the Manufacturing of Inhalable NSAID Powders
المؤلفون المشاركون
Rita Patrizia, Aquino
Mariateresa, Stigliani
Pasquale, Del Gaudio
Teresa, Mencherini
Francesca, Sansone
Paola, Russo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
The aim of this research was to evaluate the potential of the nanospray drier as a novel apparatus for the manufacturing of a dry powder for inhalation containing ketoprofen lysinate, a nonsteroidal anti-inflammatory drug able to control the inflammation in cystic fibrosis patients.
We produced several ketoprofen lysinate and leucine powder batches by means of nanospray dryer, studying the influence of process parameters on yield, particle properties (size distribution and morphology), and, mainly, aerodynamic properties of powders.
Micronized particles were prepared from different hydroalcoholic solutions (alcohol content from 0 to 30% v/v) using ketoprofen in its lysine salt form and leucine as dispersibility enhancer in different ratios (from 5 to 15% w/w) with a total solid concentration ranging from 1 to 7% w/v.
Results indicated that the spray head equipped with a 7 µm nozzle produced powders too big to be inhaled.
The reduction of nozzle size from 7 to 4 µm led to smaller particles suitable for inhalation but, at the same time, caused a dramatic increase in process time.
The selection of process variables, together with the nozzle pretreatment with a surfactant solution, allowed us to obtain a free flowing powder with satisfying aerosol performance, confirming the usefulness of the nanospray drier in the production of powder for inhalation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rita Patrizia, Aquino& Mariateresa, Stigliani& Pasquale, Del Gaudio& Teresa, Mencherini& Francesca, Sansone& Paola, Russo. 2014. Nanospray Drying as a Novel Technique for the Manufacturing of Inhalable NSAID Powders. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051279
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rita Patrizia, Aquino…[et al.]. Nanospray Drying as a Novel Technique for the Manufacturing of Inhalable NSAID Powders. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1051279
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rita Patrizia, Aquino& Mariateresa, Stigliani& Pasquale, Del Gaudio& Teresa, Mencherini& Francesca, Sansone& Paola, Russo. Nanospray Drying as a Novel Technique for the Manufacturing of Inhalable NSAID Powders. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051279
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1051279
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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