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Design, Synthesis, Molecular Docking, and Antibacterial Evaluation of Some Novel Flouroquinolone Derivatives as Potent Antibacterial Agent
المؤلفون المشاركون
Patel, Mehul M.
Patel, Laxman J.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Objective.
Quinolone moiety is an important class of nitrogen containing heterocycles widely used as key building blocks for medicinal agents.
It exhibits a wide spectrum of pharmacophores and has bactericidal, antiviral, antimalarial, and anticancer activities.
In view of the reported antimicrobial activity of various fluoroquinolones, the importance of the C-7 substituents is that they exhibit potent antimicrobial activities.
Our objective was to synthesize newer quinolone analogues with increasing bulk at C-7 position of the main 6-fluoroquinolone scaffold to produce the target compounds which have potent antimicrobial activity.
Methods.
A novel series of 1-ethyl-6-fluoro-4-oxo-7- { 4-[2-(4-substituted phenyl)-2-(substituted)-ethyl]-1-piperazinyl } -1,4-dihydroquinoline-3-carboxylic acid derivatives were synthesized.
To understand the interaction of binding sites with bacterial protein receptor, the docking study was performed using topoisomerase II DNA gyrase enzymes (PDB ID: 2XCT) by Schrodinger’s Maestro program.
In vitro antibacterial activity of the synthesized compounds was studied and the MIC value was calculated by the broth dilution method.
Results.
Among all the synthesized compounds, some compounds showed potent antimicrobial activity.
The compound 8g exhibited good antibacterial activity.
Conclusion.
This investigation identified the potent antibacterial agents against certain infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Patel, Mehul M.& Patel, Laxman J.. 2014. Design, Synthesis, Molecular Docking, and Antibacterial Evaluation of Some Novel Flouroquinolone Derivatives as Potent Antibacterial Agent. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051503
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Patel, Mehul M.& Patel, Laxman J.. Design, Synthesis, Molecular Docking, and Antibacterial Evaluation of Some Novel Flouroquinolone Derivatives as Potent Antibacterial Agent. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1051503
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Patel, Mehul M.& Patel, Laxman J.. Design, Synthesis, Molecular Docking, and Antibacterial Evaluation of Some Novel Flouroquinolone Derivatives as Potent Antibacterial Agent. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051503
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1051503
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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