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Overexpression of MMP13 Is Associated with Clinical Outcomes and Poor Prognosis in Oral Squamous Cell Carcinoma
المؤلفون المشاركون
Kallarakkal, Thomas George
Prepageran, Narayanan
Vincent-Chong, Vui King
Salahshourifar, Iman
Karen-Ng, Lee Peng
Siow, Ming Yhong
Ramanathan, Anand
Yang, Yi-Hsin
Khor, Goot Heah
Rahman, Zainal Ariff Abdul
Ismail, Siti Mazlipah
Wan Mustafa, Wan Mahadzir
Abraham, Mannil Thomas
Tay, Keng Kiong
Cheong, Sok Ching
Zain, Rosnah Binti
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Matrix metalloproteinase 13 (MMP13) plays a central role in the MMP activation cascade that enables degradation of the extracellular matrix and basement membranes, and it is identified as a potential driver in oral carcinogenesis.
Therefore, this study aims to determine the copy number, mRNA, and protein expression of MMP13 in oral squamous cell carcinoma (OSCC) and to associate these expressions with clinicopathological parameters.
Copy number, mRNA, and protein expression analysis of MMP13 were determined using real-time quantitative PCR and immunohistochemistry methods in OSCC samples.
The correlations between MMP13 expressions and clinicopathological parameters were evaluated, and the significance of MMP13 as a prognostic factor was determined.
Despite discrepancies between gene amplification and mRNA and protein overexpression rates, OSCC cases showed high amplification of MMP13 and overexpression of MMP13 at both mRNA and protein levels.
High level of MMP13 protein expression showed a significant correlation with lymph node metastasis (P=0.011) and tumor staging (P=0.002).
Multivariate Cox regression model analysis revealed that high level of mRNA and protein expression of MMP13 were significantly associated with poor prognosis (P<0.050).
Taken together, these observations indicate that the MMP13 protein overexpression could be considered as a prognostic marker of OSCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vincent-Chong, Vui King& Salahshourifar, Iman& Karen-Ng, Lee Peng& Siow, Ming Yhong& Kallarakkal, Thomas George& Ramanathan, Anand…[et al.]. 2014. Overexpression of MMP13 Is Associated with Clinical Outcomes and Poor Prognosis in Oral Squamous Cell Carcinoma. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1051507
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vincent-Chong, Vui King…[et al.]. Overexpression of MMP13 Is Associated with Clinical Outcomes and Poor Prognosis in Oral Squamous Cell Carcinoma. The Scientific World Journal No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1051507
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vincent-Chong, Vui King& Salahshourifar, Iman& Karen-Ng, Lee Peng& Siow, Ming Yhong& Kallarakkal, Thomas George& Ramanathan, Anand…[et al.]. Overexpression of MMP13 Is Associated with Clinical Outcomes and Poor Prognosis in Oral Squamous Cell Carcinoma. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1051507
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1051507
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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