Voltage Dependent Anion Channel Is Redistributed during Japanese Encephalitis Virus Infection of Insect Cells
المؤلفون المشاركون
Roytrakul, Sittiruk
Fongsaran, Chanida
Phaonakrop, Narumon
Thepparit, Chutima
Kuadkitkan, Atichat
Smith, Duncan R.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Despite the availability of an effective vaccine, Japanese encephalitis remains a significant cause of morbidity and mortality in many parts of Asia.
Japanese encephalitis is caused by the Japanese encephalitis virus (JEV), a mosquito transmitted flavivirus.
Many of the details of the virus replication cycle in mosquito cells remain unknown.
This study sought to determine whether GRP78, a well-characterized flavivirus E protein interacting protein, interacted with JEV E protein in insect cells, and whether this interaction was mediated at the cell surface.
GRP78 was shown to interact with JEV E protein by coimmunoprecipitation, and was additionally shown to interact with voltage dependent anion protein (VDAC) through the same methodology.
Antibody inhibition experiments showed that neither GRP78 nor VDAC played a role in JEV internalization to insect cells.
Interestingly, VDAC was shown to be significantly relocalized in response to JEV infection, and significant levels of colocalization between VDAC and GRP78 and VDAC and ribosomal L28 protein were seen in JEV infected but not uninfected cells.
This is the first report of relocalization of VDAC in response to JEV infection and suggests that this may be a part of the JEV replication strategy in insect cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fongsaran, Chanida& Phaonakrop, Narumon& Roytrakul, Sittiruk& Thepparit, Chutima& Kuadkitkan, Atichat& Smith, Duncan R.. 2014. Voltage Dependent Anion Channel Is Redistributed during Japanese Encephalitis Virus Infection of Insect Cells. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051834
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fongsaran, Chanida…[et al.]. Voltage Dependent Anion Channel Is Redistributed during Japanese Encephalitis Virus Infection of Insect Cells. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1051834
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fongsaran, Chanida& Phaonakrop, Narumon& Roytrakul, Sittiruk& Thepparit, Chutima& Kuadkitkan, Atichat& Smith, Duncan R.. Voltage Dependent Anion Channel Is Redistributed during Japanese Encephalitis Virus Infection of Insect Cells. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051834
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1051834
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر