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Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice
المؤلفون المشاركون
Casagrande, Rúbia
Verri, Waldiceu A.
Calixto-Campos, Cassia
Zarpelon, Ana C.
Corrêa, Mab
Crespigio, Jefferson
Hohmann, Miriam S. N.
Pinge-Filho, Phileno
Carvalho, Thacyana T.
Rossaneis, Ana C.
Coelho-Silva, Leticia
Bernardy, Catia C. F.
Pavanelli, Wander Rogério
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-13
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Cancer pain directly affects the patient’s quality of life.
We have previously demonstrated that the subcutaneous administration of the mammary adenocarcinoma known as Ehrlich tumor induces pain in mice.
Several studies have shown that the flavonoid quercetin presents important biological effects, including anti-inflammatory, antioxidant, analgesic, and antitumor activity.
Therefore, the analgesic effect and mechanisms of quercetin were evaluated in Ehrlich tumor-induced cancer pain in mice.
Intraperitoneal (i.p.) treatments with quercetin reduced Ehrlich tumor-induced mechanical and thermal hyperalgesia, but not paw thickness or histological alterations, indicating an analgesic effect without affecting tumor growth.
Regarding the analgesic mechanisms of quercetin, it inhibited the production of hyperalgesic cytokines IL-1β and TNFα and decreased neutrophil recruitment (myeloperoxidase activity) and oxidative stress.
Naloxone (opioid receptor antagonist) inhibited quercetin analgesia without interfering with neutrophil recruitment, cytokine production, and oxidative stress.
Importantly, cotreatment with morphine and quercetin at doses that were ineffective as single treatment reduced the nociceptive responses.
Concluding, quercetin reduces the Ehrlich tumor-induced cancer pain by reducing the production of hyperalgesic cytokines, neutrophil recruitment, and oxidative stress as well as by activating an opioid-dependent analgesic pathway and potentiation of morphine analgesia.
Thus, quercetin treatment seems a suitable therapeutic approach for cancer pain that merits further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Calixto-Campos, Cassia& Corrêa, Mab& Carvalho, Thacyana T.& Zarpelon, Ana C.& Hohmann, Miriam S. N.& Rossaneis, Ana C.…[et al.]. 2015. Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1052347
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Calixto-Campos, Cassia…[et al.]. Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice. Analytical Cellular Pathology No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1052347
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Calixto-Campos, Cassia& Corrêa, Mab& Carvalho, Thacyana T.& Zarpelon, Ana C.& Hohmann, Miriam S. N.& Rossaneis, Ana C.…[et al.]. Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1052347
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1052347
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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