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Cardiorenal Syndrome Type 5: In Vitro Cytotoxicity Effects on Renal Tubular Cells and Inflammatory Profile
المؤلفون المشاركون
Ronco, Claudio
Brocca, Alessandra
Virzì, Grazia Maria
Pasqualin, Chiara
Pastori, Silvia
Marcante, Stefano
de Cal, Massimo
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Cardiorenal Syndrome Type 5 (CRS Type 5) reflects concomitant cardiac and renal dysfunctions in the setting of a wide spectrum of systemic disorders.
Our aim was to study in vitro effects of CRS Type 5 plasma on renal tubular cells (RTCs), in terms of cellular death and the characterization of inflammatory plasma profile in these patients.
Material and Methods.
We enrolled 11 CRS Type 5 patients from ICU and 16 healthy controls.
Plasma from patients and controls was incubated with renal tubular cells (RTCs) and cell death was evaluated.
Plasma cytokines were detected.
Results.
RTCs incubated with CRS Type 5 plasma showed significantly higher apoptosis and necrosis with respect to controls.
Plasma cytokine profile of CRS Type 5 patients was significantly different from controls: we observed the production of pro- and anti-inflammatory mediators in these patients.
Caspase-3, caspase-8, and caspase-9 were activated in cells treated with CRS Type 5 plasma compared to controls.
Conclusions.
Our results underline the cytotoxic effect of CRS Type 5 mediators on RTC viability, probably due to the activation of both intrinsic and extrinsic pathways of apoptosis and to the deregulation of cytokine release.
The consequence may be the damage of distant organs which lead to the worsening of condition of patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brocca, Alessandra& Virzì, Grazia Maria& Pasqualin, Chiara& Pastori, Silvia& Marcante, Stefano& de Cal, Massimo…[et al.]. 2015. Cardiorenal Syndrome Type 5: In Vitro Cytotoxicity Effects on Renal Tubular Cells and Inflammatory Profile. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052357
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brocca, Alessandra…[et al.]. Cardiorenal Syndrome Type 5: In Vitro Cytotoxicity Effects on Renal Tubular Cells and Inflammatory Profile. Analytical Cellular Pathology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1052357
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brocca, Alessandra& Virzì, Grazia Maria& Pasqualin, Chiara& Pastori, Silvia& Marcante, Stefano& de Cal, Massimo…[et al.]. Cardiorenal Syndrome Type 5: In Vitro Cytotoxicity Effects on Renal Tubular Cells and Inflammatory Profile. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052357
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1052357
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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