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Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis
المؤلفون المشاركون
Savov, Alexey
Nikolova, Svetla
Dikova, Milka
Dikov, Dobrin
Djerov, Assen
Atanasov, Ventseslav
Kremensky, Ivo
Dzhebir, Gyulnas
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Scoliotic human nuclei pulposi can respond to exogenous proinflammatory stimuli by secreting increased amounts of interleukin-6 (IL-6).
The G/C polymorphism of the promoter region of IL-6 gene influences levels and functional activity of the IL-6 protein.
We conducted a case-control study of eighty patients with idiopathic scoliosis (IS) and one hundred sixty healthy unrelated gender-matched controls trying to investigate the association between IS and the IL-6 promoter polymorphism at -174 position (rs1800795 G/C) in Bulgarian population.
Molecular detection of the IL-6 genotypes was performed by amplification followed by restriction technology.
The statistical analysis was performed by Pearson’s chi-squared test.
Our case-control study revealed a statistically significant association between the IL-6 (-174 G/C) functional polymorphism and susceptibility to IS.
In addition, a significant association between the IL-6 (-174 G/C) polymorphism and curve severity was detected.
IL-6 gene could be considered as susceptibility and modifying factor of idiopathic scoliosis.
The identification of molecular markers with diagnostic and prognostic value could be useful for early detection of children at risk for the development of scoliosis and for prognosis of the risk for a rapid deformity progression.
That would facilitate the therapy decisions and early stage treatment of the patient with the least invasive procedures.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nikolova, Svetla& Dikova, Milka& Dikov, Dobrin& Djerov, Assen& Dzhebir, Gyulnas& Atanasov, Ventseslav…[et al.]. 2015. Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1052362
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nikolova, Svetla…[et al.]. Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis. Analytical Cellular Pathology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1052362
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nikolova, Svetla& Dikova, Milka& Dikov, Dobrin& Djerov, Assen& Dzhebir, Gyulnas& Atanasov, Ventseslav…[et al.]. Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1052362
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1052362
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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