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High Percentage of ADAM-10 Positive Melanoma Cells Correlates with Paucity of Tumor-Infiltrating Lymphocytes but Does Not Predict Prognosis in Cutaneous Melanoma Patients
المؤلفون المشاركون
Zietek, Marcin
Leskiewicz, Marek
Matkowski, Rafal
Halon, Agnieszka
Donizy, Piotr
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
ADAM-10 (CDw156, CD156c, and kuzbanian) is a protein belonging to a superfamily of metalloproteases, enzymes capable of degrading the extracellular matrix.
ADAMs have also been shown to be primarily involved in ectodomain cleavage.
The aim of the study was to assess the expression and intracellular location of ADAM-10 in 104 primary skin melanomas and 16 metastatic lesions from regional lymph nodes.
Also, prognostic significance of ADAM-10 expression in primary tumor cells and metastatic lesion cells was evaluated during 5-year observation.
It was revealed that high expression of ADAM-10 positive cells was strictly related with lower intensity of tumor-infiltrating lymphocytes (P=0.037), which suggests that ADAM-10 regulates immunoresponse in melanoma initiation and progression.
No statistically significant correlations were found between ADAM-10 expression in primary tumor cells and nodal metastases and other histopathological parameters analyzed.
Decreased immunoreactivity of ADAM-10 in cancer cells from regional lymph nodes was correlated with worse prognosis; however this correlation was statistically nonsignificant (P=0.065).
Review of the literature shows that our study is the first one ever to describe the significance of ADAM-10 expression in correlation with detailed histopathological parameters of the primary tumor and data on long-term survival of cutaneous melanoma patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Donizy, Piotr& Zietek, Marcin& Leskiewicz, Marek& Halon, Agnieszka& Matkowski, Rafal. 2015. High Percentage of ADAM-10 Positive Melanoma Cells Correlates with Paucity of Tumor-Infiltrating Lymphocytes but Does Not Predict Prognosis in Cutaneous Melanoma Patients. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052378
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Donizy, Piotr…[et al.]. High Percentage of ADAM-10 Positive Melanoma Cells Correlates with Paucity of Tumor-Infiltrating Lymphocytes but Does Not Predict Prognosis in Cutaneous Melanoma Patients. Analytical Cellular Pathology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1052378
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Donizy, Piotr& Zietek, Marcin& Leskiewicz, Marek& Halon, Agnieszka& Matkowski, Rafal. High Percentage of ADAM-10 Positive Melanoma Cells Correlates with Paucity of Tumor-Infiltrating Lymphocytes but Does Not Predict Prognosis in Cutaneous Melanoma Patients. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052378
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1052378
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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