Insulin-Like Growth Factor and Epidermal Growth Factor Signaling in Breast Cancer Cell Growth: Focus on Endocrine Resistant Disease
المؤلفون المشاركون
Tzanakakis, George N.
Voudouri, Kallirroi
Berdiaki, Aikaterini
Tzardi, Maria
Nikitovic, Dragana
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Breast cancer is the most common type of cancer for women worldwide with a lifetime risk amounting to a staggering total of 10%.
It is well established that the endogenous synthesis of insulin-like growth factor (IGF) and epidermal growth factor (EGF) polypeptide growth factors are closely correlated to malignant transformation and all the steps of the breast cancer metastatic cascade.
Numerous studies have demonstrated that both estrogens and growth factors stimulate the proliferation of steroid-dependent tumor cells, and that the interaction between these signaling pathways occurs at several levels.
Importantly, the majority of breast cancer cases are estrogen receptor- (ER-) positive which have a more favorable prognosis and pattern of recurrence with endocrine therapy being the backbone of treatment.
Unfortunately, the majority of patients progress to endocrine therapy resistant disease (acquired resistance) whereas a proportion of patients may fail to respond to initial therapy (de novo resistance).
The IGF-I and EGF downstream signaling pathways are closely involved in the process of progression to therapy resistant disease.
Modifications in the bioavailability of these growth factors contribute critically to disease progression.
In the present review therefore, we will discuss in depth how IGF and EGF signaling participate in breast cancer pathogenesis and progression to endocrine resistant disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Voudouri, Kallirroi& Berdiaki, Aikaterini& Tzardi, Maria& Tzanakakis, George N.& Nikitovic, Dragana. 2015. Insulin-Like Growth Factor and Epidermal Growth Factor Signaling in Breast Cancer Cell Growth: Focus on Endocrine Resistant Disease. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1052379
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Voudouri, Kallirroi…[et al.]. Insulin-Like Growth Factor and Epidermal Growth Factor Signaling in Breast Cancer Cell Growth: Focus on Endocrine Resistant Disease. Analytical Cellular Pathology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1052379
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Voudouri, Kallirroi& Berdiaki, Aikaterini& Tzardi, Maria& Tzanakakis, George N.& Nikitovic, Dragana. Insulin-Like Growth Factor and Epidermal Growth Factor Signaling in Breast Cancer Cell Growth: Focus on Endocrine Resistant Disease. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1052379
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1052379
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر