Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study
المؤلفون المشاركون
Abdul Gafor, Abdul Halim
Shah, Shamsul Azhar
Alharazy, Sabah
Kong, Norella C. T.
Mohd, Marlyn
Ba’in, Arbaiyah
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-12
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Objective.
This longitudinal study aimed to determine the urine monocyte chemoattractant protein-1 (uMCP-1) levels in patients with biopsy-proven lupus nephritis (LN) at various stages of renal disease activity and to compare them to current standard markers.
Methods.
Patients with LN—active or inactive—had their uMCP-1 levels and standard disease activity markers measured at baseline and 2 and 4 months.
Urinary parameters, renal function test, serological markers, and renal SLE disease activity index-2K (renal SLEDAI-2K) were analyzed to determine their associations with uMCP-1.
Results.
A hundred patients completed the study.
At each visit, uMCP-1 levels (pg/mg creatinine) were significantly higher in the active group especially with relapses and were significantly associated with proteinuria and renal SLEDAI-2K.
Receiver operating characteristic (ROC) curves showed that uMCP-1 was a potential biomarker for LN.
Whereas multiple logistic regression analysis showed that only proteinuria and serum albumin and not uMCP-1 were independent predictors of LN activity.
Conclusion.
uMCP-1 was increased in active LN.
Although uMCP-1 was not an independent predictor for LN activity, it could serve as an adjunctive marker when the clinical diagnosis of LN especially early relapse remains uncertain.
Larger and longer studies are indicated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alharazy, Sabah& Kong, Norella C. T.& Mohd, Marlyn& Shah, Shamsul Azhar& Ba’in, Arbaiyah& Abdul Gafor, Abdul Halim. 2015. Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study. Autoimmune Diseases،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1052394
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alharazy, Sabah…[et al.]. Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study. Autoimmune Diseases No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1052394
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alharazy, Sabah& Kong, Norella C. T.& Mohd, Marlyn& Shah, Shamsul Azhar& Ba’in, Arbaiyah& Abdul Gafor, Abdul Halim. Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study. Autoimmune Diseases. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1052394
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1052394
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر