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Determinants of Overall and Progression-Free Survival of Nigerian Patients with Philadelphia-Positive Chronic Myeloid Leukemia
المؤلفون المشاركون
Bolarinwa, Rahman A.
Oyelese, Adesola T.
Salawu, Lateef
Durosinmi, Muheez A.
Oyekunle, Anthony
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-07
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
The tyrosine kinase inhibitors have markedly changed the disease course for patients with Ph+ and/or BCR-ABL1 + chronic myeloid leukemia (CML).
This study was embarked upon to assess the long-term effects of imatinib therapy on survival in adult Nigerian patients with CML.
Methods.
All adult patients on imatinib (400–600 mg) seen from July 2003 to December 2010 were assessed.
Male/female distribution was 171/101, with a median age of 38 (range, 20–75) years.
Overall survival (OS) and progression-free survival (PFS) were determined using the Kaplan-Meier techniques.
Results.
Of all the 272 patients, 205 were in chronic phase, 54 in accelerated phase, and five in blastic phase, at commencement of imatinib.
As at December 2010, 222 were alive.
OS at 1 and 5 years was 94% and 63%, while PFS was 89% and 54%, respectively.
Similarly, amongst the 205 patients in chronic phase, OS at 1 and 5 years was 97% and 68%, while PFS was 92% and 57%.
Conclusion.
Imatinib’s place as first-line therapy in the treatment of CML has further been reinforced in our patients, with improved survival and reduced morbidity, comparable with outcomes in other populations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oyekunle, Anthony& Bolarinwa, Rahman A.& Oyelese, Adesola T.& Salawu, Lateef& Durosinmi, Muheez A.. 2015. Determinants of Overall and Progression-Free Survival of Nigerian Patients with Philadelphia-Positive Chronic Myeloid Leukemia. Advances in Hematology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1052449
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oyekunle, Anthony…[et al.]. Determinants of Overall and Progression-Free Survival of Nigerian Patients with Philadelphia-Positive Chronic Myeloid Leukemia. Advances in Hematology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1052449
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oyekunle, Anthony& Bolarinwa, Rahman A.& Oyelese, Adesola T.& Salawu, Lateef& Durosinmi, Muheez A.. Determinants of Overall and Progression-Free Survival of Nigerian Patients with Philadelphia-Positive Chronic Myeloid Leukemia. Advances in Hematology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1052449
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1052449
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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