Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia
المؤلفون المشاركون
Charoenkwan, Pimlak
Winichakoon, Poramed
Tantiworawit, Adisak
Rattanathammethee, Thanawat
Hantrakool, Sasinee
Chai-Adisaksopha, Chatree
Rattarittamrong, Ekarat
Norasetthada, Lalita
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Nontransfusion dependent thalassemia (NTDT) is a milder form of thalassemia that does not require regular transfusion.
It is associated with many complications, which differ from that found in transfusion-dependent thalassemia (TDT).
Currently available information is mostly derived from beta-NTDT; consequently, more data is needed to describe complications found in the alpha-NTDT form of this disease.
Methods.
We retrospectively reviewed the medical records of NTDT patients from January 2012 to December 2013.
Complications related to thalassemia were reviewed and compared.
Results.
One hundred patients included 60 females with a median age of 38 years.
The majority (54 patients) had alpha-thalassemia.
Overall, 83 patients had one or more complications.
The three most common complications were cholelithiasis (35%), abnormal liver function (29%), and extramedullary hematopoiesis (EMH) (25%).
EMH, cardiomyopathy, cholelithiasis, and pulmonary hypertension were more commonly seen in beta-thalassemia.
Osteoporosis was the only complication that was more common in alpha-thalassemia.
The risk factors significantly related to EMH were beta-thalassemia type and hemoglobin < 8 g/dL.
The risk factors related to osteoporosis were female gender and age > 40 years.
Iron overload (ferritin > 800 ng/mL) was the only risk factor for abnormal liver function.
Conclusion.
The prevalence of alpha-NTDT complications was lower and different from beta-thalassemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Winichakoon, Poramed& Tantiworawit, Adisak& Rattanathammethee, Thanawat& Hantrakool, Sasinee& Chai-Adisaksopha, Chatree& Rattarittamrong, Ekarat…[et al.]. 2015. Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia. Anemia،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1053786
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Winichakoon, Poramed…[et al.]. Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia. Anemia No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1053786
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Winichakoon, Poramed& Tantiworawit, Adisak& Rattanathammethee, Thanawat& Hantrakool, Sasinee& Chai-Adisaksopha, Chatree& Rattarittamrong, Ekarat…[et al.]. Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia. Anemia. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1053786
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1053786
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر