Can Chronic Nitric Oxide Inhibition Improve Liver and Renal Dysfunction in Bile Duct Ligated Rats?
المؤلفون المشاركون
Mahmoud, Mona Fouad
Zakaria, Sara
Fahmy, Ahmed
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The aims of the present work were to study the effects of chronic NO inhibition on liver cirrhosis and to analyze its relationship with liver and kidney damage markers.
Two inhibitors of NO synthesis (inducible NO synthase (iNOS) inhibitor, aminoguanidine (AG), and nonselective NOS inhibitor, L-nitroarginine methyl ester (L-NAME)) were administered for 6 weeks to bile duct ligated (BDL) rats 3 days after surgery.
The present study showed that BDL was associated with liver injury and renal impairment.
BDL increased liver NO content and myeloperoxidase (MPO) activity.
This was corroborated by increased oxidative stress, TNF-α, TGF-1β, and MMP-13 genes overexpression.
Although both drugs reduced NO synthesis and TNF-α gene overexpression, only AG improved renal dysfunction and liver damage and reduced liver oxidative stress.
However, L-NAME exacerbated liver and renal dysfunction.
Both drugs failed to modulate TGF-1β and MMP-13 genes overexpression.
In conclusion, inhibition of NO production by constitutive nitric oxide synthase (cNOS) plays a crucial role in liver injury and renal dysfunction while inhibition of iNOS by AG has beneficial effect.
TNF-α is not the main cytokine responsible for liver injury in BDL model.
Nitric oxide inhibition did not stop the progression of cholestatic liver damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahmoud, Mona Fouad& Zakaria, Sara& Fahmy, Ahmed. 2015. Can Chronic Nitric Oxide Inhibition Improve Liver and Renal Dysfunction in Bile Duct Ligated Rats?. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1053900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mahmoud, Mona Fouad…[et al.]. Can Chronic Nitric Oxide Inhibition Improve Liver and Renal Dysfunction in Bile Duct Ligated Rats?. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1053900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahmoud, Mona Fouad& Zakaria, Sara& Fahmy, Ahmed. Can Chronic Nitric Oxide Inhibition Improve Liver and Renal Dysfunction in Bile Duct Ligated Rats?. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1053900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1053900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر