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Anti-Inflammatory Effects of Heparin and Its Derivatives: A Systematic Review
المؤلفون المشاركون
Mousavi, Sarah
Moradi, Mandana
Khorshidahmad, Tina
Motamedi, Maryam
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-12
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
Heparin, used clinically as an anticoagulant, also has anti-inflammatory properties.
The purpose of this systematic review was to provide a comprehensive review regarding the efficacy and safety of heparin and its derivatives as anti-inflammatory agents.
Methods.
We searched the following databases up to March 2012: Pub Med, Scopus, Web of Science, Ovid, Elsevier, and Google Scholar using combination of Mesh terms.
Randomized Clinical Trials (RCTs) and trials with quasi-experimental design in clinical setting published in English were included.
Quality assessments of RCTs were performed using Jadad score and Consolidated Standards of Reporting Trials (CONSORT) checklist.
Results.
A total of 280 relevant studies were reviewed and 57 studies met the inclusion criteria.
Among them 48 studies were RCTs.
About 65% of articles had score of 3 and higher according to Jadad score.
Twelve studies had a quality score > 40% according to CONSORT items.
Asthma (n=7), inflammatory bowel disease (n=5), cardiopulmonary bypass (n=8), and cataract surgery (n=6) were the most studied disease condition.
Forty studies use unfractionated heparin (UFH) for intervention; the remaining studies use low molecular weight heparin (LMWH).
Conclusion.
Despite the conflicting results, heparin seems to be a safe and effective anti-inflammatory agent; although it is shown that heparin can decrease the level of inflammatory biomarkers and improves patient conditions, still more data from larger rigorously designed studies are needed to support use of heparin as an anti-inflammatory agent in clinical setting.
However, because of the association between inflammation, atherogenesis, thrombogenesis, and cell proliferation, heparin and related compounds with pleiotropic effects may have greater therapeutic efficacy than compounds acting against a single target.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mousavi, Sarah& Moradi, Mandana& Khorshidahmad, Tina& Motamedi, Maryam. 2015. Anti-Inflammatory Effects of Heparin and Its Derivatives: A Systematic Review. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1053906
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mousavi, Sarah…[et al.]. Anti-Inflammatory Effects of Heparin and Its Derivatives: A Systematic Review. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1053906
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mousavi, Sarah& Moradi, Mandana& Khorshidahmad, Tina& Motamedi, Maryam. Anti-Inflammatory Effects of Heparin and Its Derivatives: A Systematic Review. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1053906
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1053906
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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