Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats
المؤلفون المشاركون
Deb, Debasree
Bairy, K. L.
Nayak, Veena
Mohandas Rao, K. G.
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Lisinopril and fosinopril were compared on scopolamine-induced learning and memory deficits in rats.
A total of eighty-four male Wistar rats were divided into seven groups.
Group I received 2% gum acacia orally for 4 weeks, group II received normal saline, and group III received scopolamine (2 mg/kg/ip) as single dose.
Groups IV and V received lisinopril ( 0.225 mg/kg and 0.45 mg/kg), while Groups VI and VII received fosinopril (0.90 mg/kg and 1.80 mg/kg), respectively, orally for four weeks, followed by scopolamine (2 mg/kg/ip) given 45 minutes prior to experimental procedure.
Evaluation of learning and memory was assessed by using passive avoidance, Morris water maze, and elevated plus maze tests followed by analysis of hippocampal morphology and quantification of the number of surviving neurons.
Scopolamine induced marked impairment of memory in behavioral tests which correlated with morphological changes in hippocampus.
Pretreatment with fosinopril 1.80 mg/kg was found to significantly ameliorate the memory deficits and hippocampal degeneration induced by scopolamine.
Fosinopril exhibits antiamnesic activity, indicating its possible role in preventing memory deficits seen in dementia though the precise mechanism underlying this effect needs to be further evaluated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deb, Debasree& Bairy, K. L.& Nayak, Veena& Mohandas Rao, K. G.. 2015. Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1053907
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deb, Debasree…[et al.]. Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1053907
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deb, Debasree& Bairy, K. L.& Nayak, Veena& Mohandas Rao, K. G.. Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1053907
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1053907
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر