![](/images/graphics-bg.png)
Role of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 after Bradykinin Administration in Ovariectomized Estradiol-Treated Rats
المؤلفون المشاركون
Dehghani, Aghdas
Saberi, Shadan
Nematbakhsh, Mehdi
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
The accompanied role of Mas receptor (MasR), bradykinin (BK), and female sex hormone on renal blood flow (RBF) response to angiotensin 1-7 is not well defined.
We investigated the role of MasR antagonist (A779) and BK on RBF response to Ang 1-7 infusion in ovariectomized estradiol-treated rats.
Methods.
Ovariectomized Wistar rats received estradiol (OVE) or vehicle (OV) for two weeks.
Catheterized animals were subjected to BK and A799 infusion and mean arterial pressure (MAP), RBF, and renal vascular resistance (RVR) responses to Ang 1-7 (0, 100, and 300 ng kg−1 min−1) were determined.
Results.
Percentage change of RBF (%RBF) in response to Ang1-7 infusion increased in a dose-dependent manner.
In the presence of BK, when MasR was not blocked, %RBF response to Ang 1-7 in OVE group was greater than OV group significantly ( P < 0.05 ).
Infusion of 300 ng kg−1 min−1 Ang 1-7 increased RBF by 6.9 ± 1.9 % in OVE group versus 0.9 ± 1.8 % in OV group.
However when MasR was blocked, %RBF response to Ang 1-7 in OV group was greater than OVE group insignificantly.
Conclusion.
Coadministration of BK and A779 compared to BK alone increased RBF response to Ang 1-7 in vehicle treated rats.
Such observation was not seen in estradiol treated rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dehghani, Aghdas& Saberi, Shadan& Nematbakhsh, Mehdi. 2015. Role of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 after Bradykinin Administration in Ovariectomized Estradiol-Treated Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1053913
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dehghani, Aghdas…[et al.]. Role of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 after Bradykinin Administration in Ovariectomized Estradiol-Treated Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1053913
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dehghani, Aghdas& Saberi, Shadan& Nematbakhsh, Mehdi. Role of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 after Bradykinin Administration in Ovariectomized Estradiol-Treated Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1053913
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1053913
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)