Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies
المؤلفون المشاركون
Robledo, Sara M.
Cardona, Wilson
Ligardo, Karen
Henao, Jéssica
Arbeláez, Natalia
Montoya, Andrés
Alzate, Fernando
Pérez, Juan M.
Arango, Victor
Vélez, Iván D.
Sáez, Jairo
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Species of Picramnia genus are used in folk medicine to treat or prevent skin disorders, but only few species have been studied for biological activity and chemical composition.
P.
gracilis Tul.
is a native species from Central and South America and although its fruits are edible, phytochemical analysis or medicinal uses of this species are not known.
In the search of candidates to antileishmanial drugs, this work aimed to evaluate the antileishmanial activity of P.
gracilis Tul.
in in vitro and in vivo studies.
Only ethanolic extract of fruits showed leishmanicidal activity.
The majoritarian metabolite was 5,3′-hydroxy-7,4′-dimethoxyflavanone ether that exhibited high activity against L.
(V.) panamensis (EC50 17.0 + 2.8 mg/mL, 53.7 μM) and low toxicity on mammalian U-937 cells, with an index of selectivity >11.8.
In vivo studies showed that the flavanone administered in solution (2 mg/kg/day) or cream (2%) induces clinical improvement and no toxicity in hamsters with CL.
In conclusion, this is the first report about isolation of 5,3′-hydroxy-7,4′-dimethoxyflavanone of P.
gracilis Tul.
The leishmanicidal activity attributed to this flavanone is also reported for the first time.
Finally, the in vitro and in vivo leishmanicidal activity reported here for 5,3′-hydroxy-7,4′-dimethoxyflavanone offers a greater prospect towards antileishmanial drug discovery and development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Robledo, Sara M.& Cardona, Wilson& Ligardo, Karen& Henao, Jéssica& Arbeláez, Natalia& Montoya, Andrés…[et al.]. 2015. Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1053916
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Robledo, Sara M.…[et al.]. Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1053916
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Robledo, Sara M.& Cardona, Wilson& Ligardo, Karen& Henao, Jéssica& Arbeláez, Natalia& Montoya, Andrés…[et al.]. Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1053916
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1053916
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر