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Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis
المؤلفون المشاركون
Manet, Evelyne
Ainouze, Michelle
Brunel, Joanna
Gerlier, Denis
Buckland, Robin
Kweder, Hasan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Subacute Sclerosing Panencephalitis (SSPE), a rare lethal disease of children and young adults due to persistence of measles virus (MeV) in the brain, is caused by wild type (wt) MeV.
Why MeV vaccine strains never cause SSPE is completely unknown.
Hypothesizing that this phenotypic difference could potentially be represented by a molecular marker, we compared glycoprotein and matrix (M) genes from SSPE cases with those from the Moraten vaccine strain, searching for differential structural motifs.
We observed that all known SSPE viruses have residues P64, E89, and A209 (PEA) in their M proteins whereas the equivalent residues for vaccine strains are either S64, K89, and T209 (SKT) as in Moraten or PKT.
Through the construction of MeV recombinants, we have obtained evidence that the wt MeV-M protein PEA motif, in particular A209, is linked to increased viral spread.
Importantly, for the 10 wt genotypes (of 23) that have had their M proteins sequenced, 9 have the PEA motif, the exception being B3, which has PET.
Interestingly, cases of SSPE caused by genotype B3 have yet to be reported.
In conclusion, our results strongly suggest that the PEA motif is a molecular marker for wt MeV at risk to cause SSPE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kweder, Hasan& Ainouze, Michelle& Brunel, Joanna& Gerlier, Denis& Manet, Evelyne& Buckland, Robin. 2015. Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis. Advances in Virology،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054033
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kweder, Hasan…[et al.]. Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis. Advances in Virology No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1054033
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kweder, Hasan& Ainouze, Michelle& Brunel, Joanna& Gerlier, Denis& Manet, Evelyne& Buckland, Robin. Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis. Advances in Virology. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054033
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054033
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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