![](/images/graphics-bg.png)
Evaluating Andrographolide as a Potent Inhibitor of NS3-4A Protease and Its Drug-Resistant Mutants Using In Silico Approaches
المؤلفون المشاركون
Chandramohan, Vivek
Kaphle, Anubhav
Chekuri, Mamatha
Gangarudraiah, Sindhu
Bychapur Siddaiah, Gowrishankar
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Current combination therapy of PEG-INF and ribavirin against the Hepatitis C Virus (HCV) genotype-1 infections is ineffective in maintaining sustained viral response in 50% of the infection cases.
New compounds in the form of protease inhibitors can complement the combination therapy.
Asunaprevir is new to the drug regiment as the NS3-4A protease inhibitor, but it is susceptible to two mutations, namely, R155K and D168A in the protein.
Thus, in our study, we sought to evaluate Andrographolide, a labdane-diterpenoid from the Andrographis paniculata plant as an effective compound for inhibiting the NS3-4A protease as well as its concomitant drug-resistant mutants by using molecular docking and dynamic simulations.
Our study shows that Andrographolide has best docking scores of −15.0862, −15.2322, and −13.9072 compared to those of Asunaprevir −3.7159, −2.6431, and −5.4149 with wild-type R155K and D168A mutants, respectively.
Also, as shown in the MD simulations, the compound was good in binding the target proteins and maintains strong bonds causing very less to negligible perturbation in the protein backbone structures.
Our results validate the susceptibility of Asunaprevir to protein variants as seen from our docking studies and trajectory period analysis.
Therefore, from our study, we hope to add one more option in the drug regiment to tackle drug resistance in HCV infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chandramohan, Vivek& Kaphle, Anubhav& Chekuri, Mamatha& Gangarudraiah, Sindhu& Bychapur Siddaiah, Gowrishankar. 2015. Evaluating Andrographolide as a Potent Inhibitor of NS3-4A Protease and Its Drug-Resistant Mutants Using In Silico Approaches. Advances in Virology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054036
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chandramohan, Vivek…[et al.]. Evaluating Andrographolide as a Potent Inhibitor of NS3-4A Protease and Its Drug-Resistant Mutants Using In Silico Approaches. Advances in Virology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054036
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chandramohan, Vivek& Kaphle, Anubhav& Chekuri, Mamatha& Gangarudraiah, Sindhu& Bychapur Siddaiah, Gowrishankar. Evaluating Andrographolide as a Potent Inhibitor of NS3-4A Protease and Its Drug-Resistant Mutants Using In Silico Approaches. Advances in Virology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054036
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054036
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)