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Therapeutic Efficacy of E-64-d, a Selective Calpain Inhibitor, in Experimental Acute Spinal Cord Injury
المؤلفون المشاركون
Zhang, Zifeng
Huang, Zheng
Dai, Hao
Wei, Licheng
Sun, Songtao
Gao, Feng
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This study aims to investigate the therapeutic effect of calpain inhibitor E-64-d on SCI and to find a new approach to treat SCI.
When an SCI rat model was established, it was immediately administered with E-64-d.
RT-PCR and Western blotting were used to determine the protein and mRNA levels of calpain 1 and 68-kD NFP.
TUNEL staining and NeuN labeling were performed to analyze neuronal apoptosis in the lesion.
Immunohistochemistry assay was carried out to observe the expressions of calpain 1 and GFAP.
Cyclooxygenase-2 activity was measured to show the immune response status.
Locomotor function was evaluated by inclined plane test and Basso, Beattie, and Bresnahan locomotor rating scale.
The results showed that calpain 1 was activated after SCI occurred.
Treatment with E-64-d decreased expressions of calpain 1 and GFAP, alleviated neuronal apoptosis, inhibited cyclooxygenase-2 activity, and resulted in the promoted locomotor function.
Furthermore, combination of E-64-d and MP had better efficacy than did E-64-d or MP alone.
E-64-d is expected to be applied to treat SCI, and its alliance with MP may provide a valid strategy for SCI therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Zifeng& Huang, Zheng& Dai, Hao& Wei, Licheng& Sun, Songtao& Gao, Feng. 2015. Therapeutic Efficacy of E-64-d, a Selective Calpain Inhibitor, in Experimental Acute Spinal Cord Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054309
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Zifeng…[et al.]. Therapeutic Efficacy of E-64-d, a Selective Calpain Inhibitor, in Experimental Acute Spinal Cord Injury. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054309
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Zifeng& Huang, Zheng& Dai, Hao& Wei, Licheng& Sun, Songtao& Gao, Feng. Therapeutic Efficacy of E-64-d, a Selective Calpain Inhibitor, in Experimental Acute Spinal Cord Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054309
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054309
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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