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Discovering Distinct Functional Modules of Specific Cancer Types Using Protein-Protein Interaction Networks
المؤلفون المشاركون
Shen, Ru
Guda, Chittibabu
Wang, Xiaosheng
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
The molecular profiles exhibited in different cancer types are very different; hence, discovering distinct functional modules associated with specific cancer types is very important to understand the distinct functions associated with them.
Protein-protein interaction networks carry vital information about molecular interactions in cellular systems, and identification of functional modules (subgraphs) in these networks is one of the most important applications of biological network analysis.
Results.
In this study, we developed a new graph theory based method to identify distinct functional modules from nine different cancer protein-protein interaction networks.
The method is composed of three major steps: (i) extracting modules from protein-protein interaction networks using network clustering algorithms; (ii) identifying distinct subgraphs from the derived modules; and (iii) identifying distinct subgraph patterns from distinct subgraphs.
The subgraph patterns were evaluated using experimentally determined cancer-specific protein-protein interaction data from the Ingenuity knowledgebase, to identify distinct functional modules that are specific to each cancer type.
Conclusion.
We identified cancer-type specific subgraph patterns that may represent the functional modules involved in the molecular pathogenesis of different cancer types.
Our method can serve as an effective tool to discover cancer-type specific functional modules from large protein-protein interaction networks.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shen, Ru& Wang, Xiaosheng& Guda, Chittibabu. 2015. Discovering Distinct Functional Modules of Specific Cancer Types Using Protein-Protein Interaction Networks. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054361
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shen, Ru…[et al.]. Discovering Distinct Functional Modules of Specific Cancer Types Using Protein-Protein Interaction Networks. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054361
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shen, Ru& Wang, Xiaosheng& Guda, Chittibabu. Discovering Distinct Functional Modules of Specific Cancer Types Using Protein-Protein Interaction Networks. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054361
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054361
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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