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B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma
المؤلفون المشاركون
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Increasing evidences have demonstrated that B7-H4 is associated with tumor development and prognosis.
However, the clinical significance of B7-H4 expression in human osteosarcoma (OS) remains unclear.
The aim of present study was to examine the B7-H4 expression and to explore its contribution in OS.
B7-H4 expression in OS tissues was examined by immunohistochemistry.
Soluble B7-H4 (sB7-H4) levels in blood were examined by ELISA.
The association of B7-H4 expression with clinicopathological factors or prognosis was statistically analyzed.
Our findings demonstrated that B7-H4 expression in OS tissues was significantly higher than those in paired normal bone tissues ( P < 0.001 ).
sB7-H4 level in OS serum samples was significantly higher than that in healthy controls ( P = 0.005 ).
High B7-H4 expression in tissues and sB7-H4 level were both correlated with advanced tumor stage ( P < 0.001 , P = 0.017 , resp.) and distant metastasis ( P = 0.034 , P = 0.021 , resp.).
Additionally, high B7-H4 expression or serum sB7-H4 levels were significantly related to poor overall survival ( P = 0.028 , P = 0.005 , resp.).
B7-H4 in tissues and serum samples were an independent factor for affecting the survival time of OS patients ( P = 0.004 , P = 0.041 , resp.).
Collectively, our data suggest that the evaluation of B7-H4 expression in tissues and blood is a useful tool for predicting the progression of osteosarcoma and prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dong, Qiang& Ma, Xinlong. 2015. B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054400
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dong, Qiang& Ma, Xinlong. B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054400
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dong, Qiang& Ma, Xinlong. B7-H4 Expression Is Associated with Tumor Progression and Prognosis in Patients with Osteosarcoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054400
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054400
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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