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CK2 Secreted by Leishmania braziliensis Mediates Macrophage Association Invasion: A Comparative Study between Virulent and Avirulent Promastigotes
المؤلفون المشاركون
Zylbersztejn, Ana Madeira Brito
de Morais, Carlos Gustavo Vieira
Souza, Joyce Eliza de Oliveira
Lopes, Angela Hampshire
Dutra, Patrícia Maria Lourenço
Amaral Gonçalves da Silva, S.
Silva-Neto, Mário A. C.
Castro Lima, Ana Karina
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
CK2 is a protein kinase distributed in different compartments of Leishmania braziliensis: an externally oriented ecto-CK2, an intracellular CK2, and a secreted CK2.
This latter form is constitutively secreted from the parasite (CsCK2), but such secretion may be highly enhanced by the association of specific molecules, including enzyme substrates, which lead to a higher enzymatic activity, called inductively secreted CK2 (IsCK2).
Here, we examined the influence of secreted CK2 (sCK2) activity on the infectivity of a virulent L.
braziliensis strain.
The virulent strain presented 121-fold higher total CK2 activity than those found in an avirulent strain.
The use of specific CK2 inhibitors (TBB, DRB, or heparin) inhibited virulent parasite growth, whereas no effect was observed in the avirulent parasites.
When these inhibitors were added to the interaction assays between the virulent L.
braziliensis strain and macrophages, association index was drastically inhibited.
Polyamines enhanced sCK2 activity and increased the association index between parasites and macrophages.
Finally, sCK2 and the supernatant of the virulent strain increased the association index between the avirulent strain and macrophages, which was inhibited by TBB.
Thus, the kinase enzyme CK2 seems to be important to invasion mechanisms of L.
braziliensis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zylbersztejn, Ana Madeira Brito& de Morais, Carlos Gustavo Vieira& Castro Lima, Ana Karina& Souza, Joyce Eliza de Oliveira& Lopes, Angela Hampshire& Amaral Gonçalves da Silva, S.…[et al.]. 2015. CK2 Secreted by Leishmania braziliensis Mediates Macrophage Association Invasion: A Comparative Study between Virulent and Avirulent Promastigotes. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054453
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zylbersztejn, Ana Madeira Brito…[et al.]. CK2 Secreted by Leishmania braziliensis Mediates Macrophage Association Invasion: A Comparative Study between Virulent and Avirulent Promastigotes. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054453
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zylbersztejn, Ana Madeira Brito& de Morais, Carlos Gustavo Vieira& Castro Lima, Ana Karina& Souza, Joyce Eliza de Oliveira& Lopes, Angela Hampshire& Amaral Gonçalves da Silva, S.…[et al.]. CK2 Secreted by Leishmania braziliensis Mediates Macrophage Association Invasion: A Comparative Study between Virulent and Avirulent Promastigotes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054453
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054453
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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